Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma

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dc.authoridDonghia, Rossella/0000-0002-9140-673X
dc.contributor.authorCarr, B. I.
dc.contributor.authorGuerra, V.
dc.contributor.authorDonghia, R.
dc.date.accessioned2024-08-04T20:48:51Z
dc.date.available2024-08-04T20:48:51Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Macroscopic portal vein thrombosis (PVT) is a major poor prognosis factor in patients with hepatocellular carcinoma (HCC). Inflammation is increasingly recognized to be part of the hepatocarcinogenic process and its markers are also prognostically useful. Aims To examine the relationship of inflammation biomarkers to the presence of PVT and to survival in PVT patients with HCC. Methods A large HCC cohort was examined for the presence of PVT and analyzed retrospectively. Results Blood levels of NLR, PLR, ESR, CRP, AFP and GGTP were significantly related to the presence of PVT, but not the Glasgow Index. For patients with low alpha-fetoprotein levels, blood ESR and GGTP levels were also significantly increased in patients with PVT compared with those in patients without PVT. In a Cox regression model, serum GGTP levels had a significantly increased hazard ratio on death (1.52,p = 0.008). Kaplan-Meier analysis showed that PVT patients with low serum GGTP levels had significantly longer survival than PVT patients with high GGTP levels (p = 0.0041). Conclusions Indices of inflammation, especially serum GGTP levels, related significantly to the presence of PVT and to survival in HCC patients with PVT.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1007/s12029-020-00489-7
dc.identifier.endpage1147en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32851544en_US
dc.identifier.scopus2-s2.0-85089905332en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1141en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00489-7
dc.identifier.urihttps://hdl.handle.net/11616/99495
dc.identifier.volume51en_US
dc.identifier.wosWOS:000565029000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHCCen_US
dc.subjectPVTen_US
dc.subjectNLRen_US
dc.subjectPLRen_US
dc.subjectESRen_US
dc.subjectPVTen_US
dc.subjectSurvivalen_US
dc.titlePortal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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