Effects of pinealectomy and exogenous melatonin on the brains, testes, duodena and stomachs of rats

Basit Öğe Kaydı
dc.authoridCengiz, Nureddin/0000-0002-2486-5901
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidCengiz, Nureddin/A-4949-2018
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorTasdemir, S.
dc.contributor.authorSamdanci, E.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorPolat, A.
dc.contributor.authorTasdemir, C.
dc.contributor.authorCengiz, N.
dc.contributor.authorSapmaz, H.
dc.date.accessioned2024-08-04T20:36:01Z
dc.date.available2024-08-04T20:36:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND, It is generally agreed that physiological levels of melatonin, a hormone secreted by the pineal gland, are important in protecting against oxidative stress-induced tissue damage. AIM, We investigated the effects that pinealectomy and the administration of exogenous melatonin have on the brains, testes, duodena and stomachs of rats. MATERIALS AND METHODS, Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, and catalase (CAT), reduced glutathione (GSH), super oxide dismutase (SOD) and malondialdehyde (MDA) levels. The rats were divided into the following five groups (eight rats in each group): sham (non-Px), Px+ vehicle, Px+ melatonin (10 mg/kg given daily intraperitoneally for a week), melatonin and ethyl alcohol. RESULTS, The antioxidant levels in the tissue of Px rats were significantly lower than in those of the sham group. Administering melatonin significantly increased antioxidant levels (p < 0.05). The Px rats also showed a significant increase in MDA levels when compared to the sham group, and administering melatonin to the Px rats significantly reduced their MDA levels (p < 0.05). The severity of caspase-3 staining was lower in the Px+ melatonin group than in the Px+ vehicle group. CONCLUSIONS, These findings suggest that significantly more oxidative and structural changes occur in rats' brains, spinal cords and testes after pinealectomy, but that this can be diminished by melatonin treatment. However, Px does not have important effects on the duodenum and stomach.en_US
dc.identifier.endpage866en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid22953632en_US
dc.identifier.scopus2-s2.0-84864192629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage860en_US
dc.identifier.urihttps://hdl.handle.net/11616/95734
dc.identifier.volume16en_US
dc.identifier.wosWOS:000306504700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinealectomyen_US
dc.subjectMelatoninen_US
dc.subjectBrainen_US
dc.subjectTestisen_US
dc.subjectDuodenumen_US
dc.subjectStomachen_US
dc.titleEffects of pinealectomy and exogenous melatonin on the brains, testes, duodena and stomachs of ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu