Relationship between serum ?-glutamyltransferase levels and acute exacerbation of chronic obstructive pulmonary disease

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dc.authoridAytemur, Zeynep Ayfer/0000-0003-0421-907X
dc.authoridErmis, Hilal/0000-0002-1764-9098
dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridÇelik, Muhammet Reha/0000-0001-8461-2909
dc.authorwosidAytemur, Zeynep Ayfer/ABI-7452-2020
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidÇelik, Muhammet Reha/AAZ-4455-2020
dc.contributor.authorErmis, Hilal
dc.contributor.authorCelik, Muhammet R.
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTavli, Deniz
dc.contributor.authorAytemur, Zeynep A.
dc.date.accessioned2024-08-04T20:37:34Z
dc.date.available2024-08-04T20:37:34Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractINTRODUCTION gamma-glutamyltransferase (GGT) is a plasma membrane enzyme, which is involved in antioxidant glutathione resynthesis. OBJECTIVES The aim of the study was to compare the serum levels of GGT (which is considered a novel marker of oxidative stress) between patients with stable chronic obstructive pulmonary disease (COPD) and those with acute exacerbation of COPD, and the relationship of GGT with inflammation. PATIENTS AND METHODS The study involved 132 patients with exacerbated COPD and normal function of the liver and biliary tract (mean age, 66.6 +/- 10.1 years; men, 88.6%) and 147 patients with stable COPD (mean age, 65.4 +/- 8.8 years; men, 87.1%). Serum GGT and C-reactive protein (CRP) levels were measured and compared between the groups. RESULTS Serum GGT levels in patients with exacerbated COPD were significantly higher than in those with stable COPD (30 U/l; interquartile range [IQR], 18.8 vs. 25 U/l; IQR, 16; P < 0.001]. Serum CRP levels were significantly higher in patients with exacerbated COPD compared with those with stable COPD (34 mg/l; IQR, 58.3 vs. 16 mg/l; IQR, 24.6; P < 0.001). A significant positive correlation was observed between GGT activity and CRP levels (r = 0.27, P = 0.002). The GGT level of 29 U/l was set as a cutoff value of acute exacerbation with the specificity of 70.1% and sensitivity of 62.8% (95% confidence interval, 0.6-0.71; area under the curve, 0.66; standard error, 0.032; P < 0.001). CONCLUSIONS Our study indicates that serum GGT levels as the marker of oxidative stress increase during exacerbated COPD and correlate with CRP levels. The measurement of GGT activity may be useful in the evaluation of exacerbated COPD.en_US
dc.identifier.doi10.20452/pamw.1617
dc.identifier.endpage90en_US
dc.identifier.issn0032-3772
dc.identifier.issue3en_US
dc.identifier.pmid23344614en_US
dc.identifier.scopus2-s2.0-84877303612en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.20452/pamw.1617
dc.identifier.urihttps://hdl.handle.net/11616/96053
dc.identifier.volume123en_US
dc.identifier.wosWOS:000316795800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedycyna Praktycznaen_US
dc.relation.ispartofPolskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgamma-glutamyltransferaseen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectexacerbationen_US
dc.subjectoxidative stressen_US
dc.titleRelationship between serum ?-glutamyltransferase levels and acute exacerbation of chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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