The effects of propofol-ketamine combination on QTc interval in patients with coronary artery disease

dc.contributor.authorKoca, Erdinc
dc.contributor.authorAkgul Erdil, Feray
dc.contributor.authorToprak, Huseyin Ilksen
dc.contributor.authorGulhas, Nurcin
dc.contributor.authorErsoy, Ozcan
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2022-12-05T11:39:04Z
dc.date.available2022-12-05T11:39:04Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the effects of propofol-ketamine combination on QTc, T wave (Tp-e) interval, hemodynamics during the induction of anesthesia in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG). Patients were prospectively randomized, in a double blinded manner, to either the propofol group (Group P, n=41) or the propofol-ketamine combination group (Group PK, n=45). In both groups the drugs were infused at an IV dose of 2 mg/kg administered over 30 seconds. After that, 5?g/kg fentanyl and 0.1mg/kg vecuronium were administered and tracheal intubation was performed. ECG recordings were performed prior to induction of anesthesia (baseline, T1), 2 min after the beginning of study drugs (T2), 3 min after vecuronium (immediately before intubation, T3), and 30 s (T4), 1 min (T5) and 5 min (T6) after intubation. Eighty-six patients were evaluated in the study. The baseline QTc interval values were similar between the groups, In Group P, QTc interval increased significantly for T3-T6 in all periods according to baseline value. Also in Group P, QTc interval increased significantly in T4, T5, T6 according to T3. In group PK, QTc interval increased significantly in T3-T6 according to baseline value. Group PK increased significantly in T5 and T6 compared to T3. In both groups a statistically significant change was not found in Tp-e intervals of all periods. Following induction with propofol-ketamine combination, QTc interval did not increase, but it prolonged postintubation QTc interval just like propofol. Assuming that increased repolarization transmural dispersion (TDR) is a reliable indicator of risk of torsade de pointes (TdP), and lack of any change in Tp-e interval, in the presence of depressed hemodynamic response to intubation, we think that this combination can be safely used for the induction of anesthesia in patients with CAD undergoing CABG.en_US
dc.identifier.citationKOCA E, ERDÄ°L F, TOPRAK H, GULHAS N, ERSOY O, DURMUS M (2021). The effects of propofol-ketamine combination on QTc interval in patients with coronary artery disease. Medicine Science, 10(2), 278 - 282.en_US
dc.identifier.endpage282en_US
dc.identifier.issn2147-0634
dc.identifier.issue2en_US
dc.identifier.startpage278en_US
dc.identifier.trdizinid489033en_US
dc.identifier.urihttps://hdl.handle.net/11616/85572
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/489033
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of propofol-ketamine combination on QTc interval in patients with coronary artery diseaseen_US
dc.typeArticleen_US

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