The effects of propofol-ketamine combination on QTc interval in patients with coronary artery disease
| dc.contributor.author | Koca, Erdinc | |
| dc.contributor.author | Akgul Erdil, Feray | |
| dc.contributor.author | Toprak, Huseyin Ilksen | |
| dc.contributor.author | Gulhas, Nurcin | |
| dc.contributor.author | Ersoy, Ozcan | |
| dc.contributor.author | Durmus, Mahmut | |
| dc.date.accessioned | 2022-12-05T11:39:04Z | |
| dc.date.available | 2022-12-05T11:39:04Z | |
| dc.date.issued | 2021 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | The purpose of this study was to evaluate the effects of propofol-ketamine combination on QTc, T wave (Tp-e) interval, hemodynamics during the induction of anesthesia in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG). Patients were prospectively randomized, in a double blinded manner, to either the propofol group (Group P, n=41) or the propofol-ketamine combination group (Group PK, n=45). In both groups the drugs were infused at an IV dose of 2 mg/kg administered over 30 seconds. After that, 5?g/kg fentanyl and 0.1mg/kg vecuronium were administered and tracheal intubation was performed. ECG recordings were performed prior to induction of anesthesia (baseline, T1), 2 min after the beginning of study drugs (T2), 3 min after vecuronium (immediately before intubation, T3), and 30 s (T4), 1 min (T5) and 5 min (T6) after intubation. Eighty-six patients were evaluated in the study. The baseline QTc interval values were similar between the groups, In Group P, QTc interval increased significantly for T3-T6 in all periods according to baseline value. Also in Group P, QTc interval increased significantly in T4, T5, T6 according to T3. In group PK, QTc interval increased significantly in T3-T6 according to baseline value. Group PK increased significantly in T5 and T6 compared to T3. In both groups a statistically significant change was not found in Tp-e intervals of all periods. Following induction with propofol-ketamine combination, QTc interval did not increase, but it prolonged postintubation QTc interval just like propofol. Assuming that increased repolarization transmural dispersion (TDR) is a reliable indicator of risk of torsade de pointes (TdP), and lack of any change in Tp-e interval, in the presence of depressed hemodynamic response to intubation, we think that this combination can be safely used for the induction of anesthesia in patients with CAD undergoing CABG. | en_US |
| dc.identifier.citation | KOCA E, ERDÄ°L F, TOPRAK H, GULHAS N, ERSOY O, DURMUS M (2021). The effects of propofol-ketamine combination on QTc interval in patients with coronary artery disease. Medicine Science, 10(2), 278 - 282. | en_US |
| dc.identifier.endpage | 282 | en_US |
| dc.identifier.issn | 2147-0634 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 278 | en_US |
| dc.identifier.trdizinid | 489033 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/85572 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/489033 | |
| dc.identifier.volume | 10 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Medicine Science | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | The effects of propofol-ketamine combination on QTc interval in patients with coronary artery disease | en_US |
| dc.type | Article | en_US |
