An innovation in stem cell harvesting: Heparin use

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dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.contributor.authorGul, Hacer Gozde
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorSarici, Ahmet
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBerber, Ilhami
dc.contributor.authorMerter, Mustafa
dc.date.accessioned2024-08-04T20:50:33Z
dc.date.available2024-08-04T20:50:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Objectives: Stem cell transplantation is a growing treatment strategy for most malignant and nonmalignant hematological diseases. Plerixafor and granulocyte colony stimulating factor (G-CSF) are usually used in mobilization regimens to increase the CD34+ cell count in the harvest. Heparin is a sulphated glycosaminoglycated polymer with 12-15 kDa mass. Heparin inhibits the CXCR4/SDF1 axis, as does plerixafor. In this study, our aim was to investigate the effect of using heparin on stem cell mobilization and harvesting. Materials and Methods: We administered 5000 units of unfractioned heparin intravenously in 150 mL (mL) of isotonic sodium chloride solution, 15 min before the stem cell harvesting procedure to 141 patients who underwent bone marrow transplantation between the years of 2018 and 2019 at our Stem Cell Transplantation Unit. Thirty patients were included as a control group, and they were not given heparin. The study population included patients with multiple myeloma and lymphoma equally in each group. Results: In all patients hematopoeitic stem cells were successfully harvested in a single cycle of apheresis. In multiple myeloma patients who received heparin, the mean collected CD34+ cell number was 8 x 10(6)/kg, and the mean CD34+ cell number yield was 12,555/mu l. In the control group, the mean collected CD34+ cell number was 4,2 x 10(6)/kg, and mean CD34+ cell number in yield was 492/mu l. In lymphoma patients who received heparin, the mean collected CD34+ cell number was 6,8 x 10(6)/kg, and the mean CD34+ cell number was 1421/ mu l. In the control group the mean collected CD34+ cell number was 4,3 x 10(6)/kg, and the mean CD34+ cell number was 358/mu l. The effect of heparin on the collected stem cell number in both myeloma and lymphoma patients was statistically significant (p < 0.01) Conclusions: Our results have shown that heparin increases harvested stem cell numbers significantly. Heparin may be a promising agent for stem cell harvesting.en_US
dc.identifier.doi10.1016/j.transci.2021.103240
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34404617en_US
dc.identifier.scopus2-s2.0-85112520137en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103240
dc.identifier.urihttps://hdl.handle.net/11616/100128
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStem cell harvestingen_US
dc.subjectMobilizationen_US
dc.subjectHeparinen_US
dc.subjectG-CSFen_US
dc.subjectPlerixaforen_US
dc.titleAn innovation in stem cell harvesting: Heparin useen_US
dc.typeArticleen_US

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