Development of Dual-Functional Hydrogel-Based Conductive Electrodes for Accelerated Wound Healing and Motion Sensing

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dc.contributor.authorBoztepe, Cihangir
dc.contributor.authorBulucu, Firat Orhan
dc.contributor.authorZengin, Reyhan
dc.date.accessioned2026-04-04T13:37:37Z
dc.date.available2026-04-04T13:37:37Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractFlexible conductive hydrogel-based electrodes are promising for biomedical use, combining enhanced wound healing, bioelectrical signaling, and real-time motion sensing, with broad potential in personalized medicine, wearable electronics, and smart prosthetics. In this study, electrically conductive hydrogels with dual functionality were developed for accelerated wound healing and motion sensing applications. The hydrogel electrodes were synthesized via a freeze-thaw cross-linking method using polyvinyl alcohol (PVA), crystalline nanocellulose (CNC), Laponite (LAP), and polyaniline (PANI). The influence of CNC and LAP content on the electrical conductivity, mechanical strength, swelling capacity, and degradation behavior of the hydrogels was systematically investigated. The PVA-CNC-LAP/PANI hydrogel optimized for electrical conductivity (1.5 wt.% CNC and 1.25 wt.% LAP) demonstrated outstanding multifunctional performance, combining robust mechanical strength (490 kPa tensile strength, 2.57 mm/mm elongation, 162 kPa elastic modulus, and 656 kJ/m(3) toughness) with excellent electrical properties, including high conductivity (33.65 S/m), reliable sensitivity (gauge factor = 1.74), and remarkable durability (>500 cycles at 20% strain). Biocompatibility and cell migration potential of this hydrogel electrode were assessed through scratch assays using human dermal fibroblasts (HDF). Additionally, the hydrogel's performance was evaluated in flexible sensor, smart finger actuator, and electrocardiogram (ECG) electrode applications. The biocompatible PVA/CNC/PANI-LAP hydrogel electrodes exhibited satisfactory electrical conductivity, excellent mechanical integrity, and electroresponsive behavior, thereby effectively supporting HDF proliferation, directed migration, and motion detection capabilities.
dc.identifier.doi10.1002/mabi.202500409
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.orcid0000-0001-5019-2010
dc.identifier.orcid0000-0003-4558-9667
dc.identifier.pmid41268960
dc.identifier.scopus2-s2.0-105022656449
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mabi.202500409
dc.identifier.urihttps://hdl.handle.net/11616/109950
dc.identifier.wosWOS:001620635500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectbioelectronic interface
dc.subjectconductive hydrogel
dc.subjecte-patch
dc.subjectmotion sensing
dc.subjectwearable device
dc.titleDevelopment of Dual-Functional Hydrogel-Based Conductive Electrodes for Accelerated Wound Healing and Motion Sensing
dc.typeArticle

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