Interdialytic weight gain and pulmonary membrane diffusing capacity in patients on hemodialysis

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dc.authorscopusid6701745769
dc.authorscopusid7801620137
dc.authorscopusid56265702500
dc.authorscopusid6506553303
dc.authorscopusid7003361285
dc.authorscopusid6701614367
dc.authorscopusid57535532500
dc.contributor.authorTaskapan H.
dc.contributor.authorUlu R.
dc.contributor.authorGullu H.
dc.contributor.authorTaskapan M.C.
dc.contributor.authorYıldırım Z.
dc.contributor.authorKosar F.
dc.contributor.authorSahin I.
dc.date.accessioned2024-08-04T19:59:22Z
dc.date.available2024-08-04T19:59:22Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Measurement of pulmonary diffusion capacity for carbon monoxide (DLCO) may be useful for assessing disease affecting the alveolar-capillary bed or the pulmonary vasculature. It was reported that hemodialysis (HD) therapy causes DLCO reduction via decrease of pulmonary capillary blood volume components. The aim of the study was to evaluate the effect of interdialytic weight gain on pulmonary function and especially DLCO. We further determined whether intravascular volume status, assessed by inferior vena cava diameter (IVCD) contributes to DLCO in patients on HD. Methods: Routine pulmonary function testing including forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, forced mid-expiratory flow rate (FEF 25-75 ), DLCO IVCD index and other echocardiographic parameters were evaluated in 20 patients (mean age 48.6 ± 18.3 years, mean dialysis duration 17.4 ± 19.2 months) on chronic HD, 1 hour after HD and after an interdialytic period (1 hour before HD therapy). Single-breath DLCO measurements were corrected for hemoglobin concentration (cDLCO). Results: Routine pulmonary function tests (spirometry) showed no significant changes in FEV1, FVC and FEF 25-75 whereas a statistically significant fall in FEV/FVC was found. At the end of the interdialytic period a statistically significant increase in weight, IVCD index, left ventriculer diastolic diameter (LVDD), and diastolic blood pressure (DBP) were observed (P < 0.05). Using the single-breath DLCO, we found unchanged cDLCO at the end of the interdialytic period. There was no correlation of cDLCO with increases in weight, DBP, IVCD index, LVDD (P > 0.05). Conclusion: The accumulation of body water between dialyses has no significant influence on DLCO. © 2004 Kluwer Academic Publishers.en_US
dc.identifier.doi10.1007/s11255-004-8790-2
dc.identifier.endpage586en_US
dc.identifier.issn0301-1623
dc.identifier.issue4en_US
dc.identifier.pmid15787342en_US
dc.identifier.scopus2-s2.0-13444259723en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage583en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-004-8790-2
dc.identifier.urihttps://hdl.handle.net/11616/90578
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiffusion capacityen_US
dc.subjectHemodialysisen_US
dc.subjectPulmonary function testen_US
dc.titleInterdialytic weight gain and pulmonary membrane diffusing capacity in patients on hemodialysisen_US
dc.typeArticleen_US

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