The effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking density

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dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorYazlak, Hasan
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorSahin, Nurhan
dc.date.accessioned2024-08-04T20:37:54Z
dc.date.available2024-08-04T20:37:54Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLycopene, the major carotenoid found in tomato, exhibits health beneficial effects by virtue of its antioxidant activity. As stocking density is known as a stress factor in fish, the effects of dietary lycopene supplementation (0, 200 or 400 mg kg(-1)) on growth performance and antioxidant status in rainbow trout under normal (20 kg m(3-1)) and high (100 kg m(3-1)) stocking density were studied. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities were evaluated, as well as lipid peroxidation measured as malondialdehyde (MDA). Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), erythroid-derived 2-like 2 (Nrf2) and heme-oxygenase 1 (HO-1) levels were also assayed as an indicator of detoxifying/antioxidant defense mechanisms to cope with oxidative stress. Results showed that exposure to high stocking density depressed feed intake by 6.8% and body weight gain by 12.1%, increased plasma and hepatic MDA level by 88.5 and 124.3% and decreased hepatic SOD, CAT and GSH-Px activities by 22.1, 43.4 and 51.7%, respectively. In fish under crowded conditions, an expression of hepatic NF-kappa B was increased by 71.5%, being suppressed in Nrf2 and HO-1 by 40.6 and 42.7%, respectively. Lycopene supplementation increased linearly fish growth performance and antioxidant enzyme activity, and decreased linearly MDA concentration in both low and high stocking densities. NF-kappa B levels decreased hepatic Nrf2 and HO-1 levels increased linearly with lycopene supplementation at a greater extent in fish under low stocking condition. In conclusion, dietary supplementation of lycopene to fish reduces the detrimental effects of high stocking density on growth performance and modulates oxidative status via activating host defense system at cellular level. It appears that lycopene can be added up to 400 mg kg(-1) to rainbow trout diets to improve meat quality. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUnit of the Scientific Research Projects of Inonu University [2012/10]; Turkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipThe authors thank the financial support of the Unit of the Scientific Research Projects of Inonu University (Grant no: 2012/10), the Surgu Vocational School Division of Inonu University, Malatya, Turkey, for providing the experimental facility and DSM, Istanbul, Turkey, for providing the lycopene. This work was also supported in part by the Turkish Academy of Sciences (TUBA).en_US
dc.identifier.doi10.1016/j.aquaculture.2013.10.009
dc.identifier.endpage138en_US
dc.identifier.issn0044-8486
dc.identifier.issn1873-5622
dc.identifier.scopus2-s2.0-84887122248en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1016/j.aquaculture.2013.10.009
dc.identifier.urihttps://hdl.handle.net/11616/96264
dc.identifier.volume418en_US
dc.identifier.wosWOS:000326978300019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofAquacultureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLycopeneen_US
dc.subjectOxidative stressen_US
dc.subjectNuclear transcription factorsen_US
dc.subjectStocking densityen_US
dc.titleThe effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking densityen_US
dc.typeArticleen_US

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