Efficacy of Modified Talc Powder in Experimental Rat Model of Pleurodesis

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dc.contributor.authorKilic, Murat
dc.contributor.authorOzhan, Onural
dc.contributor.authorYildiz, Azibe
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAkyuz, Mustafa
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorGokturk, Nurcan
dc.date.accessioned2026-04-04T13:31:12Z
dc.date.available2026-04-04T13:31:12Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Pleurodesis is a treatment method that aims to create permanent adhesion between the pleural layers to prevent recurrent fluid or air accumulation in the pleural cavity. Talc, one of the most commonly preferred agents in this procedure, is widely used in clinical practice. In this study, a new talc formulation with a modified surface to impart antibacterial and analgesic properties was experimentally evaluated for the first time. The main objective of the study was to comparatively assess the inflammatory and fibrotic responses following standard talc and modified talc applications. Methods: Thirty-six 12-week-old female Wistar albino rats were simply randomly divided into three different groups: control (n = 12), standard talc (n = 12), and modified talc (n = 12). Under anesthesia, 1 mL of physiological saline containing 17 mg of talc was injected intrapleurally into the right hemithorax. The presence of pneumothorax after the procedure was assessed by chest radiography. After a 12-day follow-up period, the animals were euthanized. Bronchoalveolar lavage (BAL) fluid samples, blood samples, and lung and pleural tissue samples were collected for biochemical, histopathological, and immunohistochemical analyses. Results: Modified talc application resulted in a significant increase in both visceral and parietal pleural thickness (p < 0.05). Granulation tissue formation and collagen deposition were significantly higher in the modified talc group. In addition, TGF-beta expression and CD68-positive macrophage count increased significantly in the modified talc group (p < 0.05). Inflammatory changes in the lung parenchyma were limited and not statistically significant. Conclusions: The modified talc formulation enriched with lidocaine and antibacterial agents produced a stronger inflammatory and fibrotic response compared to standard talc. These findings indicate that modified talc may increase the effectiveness of pleurodesis. Furthermore, the absence of significant lung parenchymal damage suggests that this treatment is locally effective and feasible. However, further long-term and advanced studies are needed to translate these results into clinical use.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TCD-2024-3682, TSA-2025-4489]
dc.description.sponsorshipThe authors declare that no funds, grants, or other support were received during the preparation of this manuscript. This work supported by the Inonu University Scientific Research Projects Coordination Unit with the project code TCD-2024-3682 and TSA-2025-4489.
dc.identifier.doi10.3390/biom16010104
dc.identifier.issn2218-273X
dc.identifier.issue1
dc.identifier.pmid41594645
dc.identifier.scopus2-s2.0-105028846253
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/biom16010104
dc.identifier.urihttps://hdl.handle.net/11616/108648
dc.identifier.volume16
dc.identifier.wosWOS:001672363500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofBiomolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectpleurodesis
dc.subjectmodified talc
dc.subjectpleural cavity
dc.subjectlung
dc.subjectrat model
dc.titleEfficacy of Modified Talc Powder in Experimental Rat Model of Pleurodesis
dc.typeArticle

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