Neurofibromatosis type 1: Diffusion weighted imaging findings of brain

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dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridErdem, Gülnur/0000-0003-2200-8620
dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidErdem, Gülnur/GPS-7725-2022
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.contributor.authorAlkan, A
dc.contributor.authorSigirci, A
dc.contributor.authorKutlu, R
dc.contributor.authorOzcan, H
dc.contributor.authorErdem, G
dc.contributor.authorAslan, M
dc.contributor.authorAtes, O
dc.date.accessioned2024-08-04T20:15:03Z
dc.date.available2024-08-04T20:15:03Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The purposes of this study were to evaluate the differences in apparent diffusion coefficient (ADC) values between infra and supratentorial unidentified bright objects (UBOs), between UBOs and normal appearing side (NAS, contralateral regions of the UBOs and/or normal appearing region without UBOs) in the neurofibromatosis type 1 patients (NF1) and control group and also to investigate correlation between age and ADC values. Methods: A total of 30 patients and 26 healthy controls were included. The MRI examination consisted of routine imaging and diffusion weighted imaging (DWI). Seven distinct locations (frontal, parieto-occipital and cerebellar white matter, globus pallidum, thalamus, hippocampus, and midbrain) were selected for the analysis. The ADC values were calculated directly from these automatically generated ADC maps with ROI. Results: The ADC values of UBOs were significantly increased in cerebellar white matter, hippocampus, globus pallidum, midbrain, and thalamus when compared with NAS and control group. There were statistically significant differences between NAS and control group in the ADC values obtained from hippocampus and thalamus. There were statistically significant differences between supra and infratentorial UBOs in ADC values. There was a negative correlation between age and the ADC values obtained from normal appearing midbrain, hippocampus, thalamus, and globus pallidum. Conclusion: ADC values both in UBOs and in the normal appearing locations as hippocampus and thalamus were detected to be higher in the patients with NF1. The detection of lesions might be independent of MRI appearance in NF1, i.e. although the brain is affected, MRI appearance may be normal. Therefore, DWI and ADC values should also be utilized in the delineation of brain involvement of NF1 patients. (C) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2005.05.008
dc.identifier.endpage234en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue2en_US
dc.identifier.pmid15963674en_US
dc.identifier.scopus2-s2.0-26944489010en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage229en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2005.05.008
dc.identifier.urihttps://hdl.handle.net/11616/94143
dc.identifier.volume56en_US
dc.identifier.wosWOS:000233267400016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneurofibromatosis type 1en_US
dc.subjectdiffusion magnetic resonance imagingen_US
dc.subjectbrainen_US
dc.titleNeurofibromatosis type 1: Diffusion weighted imaging findings of brainen_US
dc.typeArticleen_US

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