The protective effect of apocynin on testicular ischemia reperfusion injury

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dc.authoridTR179683en_US
dc.authoridTR100549en_US
dc.authoridTR45132en_US
dc.authoridTR102000en_US
dc.authoridTR58662en_US
dc.contributor.authorÖzbek, Özkan
dc.contributor.authorAltıntaş, Ramazan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardı, Nigar
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorSağır, Mustafa
dc.contributor.authorDuran, Zeynep Rümeysa
dc.contributor.authorYıldız, Azibe
dc.date.accessioned2017-04-11T10:47:19Z
dc.date.available2017-04-11T10:47:19Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the protective effect of the NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats. Materials and Methods A total of 32 rats were randomly divided into 4 groups. Controls underwent left scrotal exploration only. The 3 groups with ischemia-reperfusion underwent 4-hour torsion followed by 1-hour detorsion. The ischemia-reperfusion only group underwent left testicular torsion and detorsion. The ischemia-reperfusion plus saline group underwent left testicular torsion, received 10 ml/kg saline intraperitoneally at minute 210 of ischemia and then underwent detorsion. The ischemia-reperfusion plus apocynin group underwent left testicular torsion, received 20 mg/kg apocynin intraperitoneally at minute 210 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. Results In the ischemia-reperfusion only and the ischemia-reperfusion plus saline groups malondialdehyde, total oxidative capacity and the oxidative stress index were significantly higher. Superoxide dismutase, catalase, glutathione peroxidase and glutathione were significantly lower. Apocynin significantly decreased malondialdehyde, total oxidative capacity and the oxidative stress index, and significantly increased superoxide dismutase and catalase. There was a significantly increase in the number of giant, degenerated and desquamated cells in the ischemia-reperfusion group. Apocynin significantly improved these histological alterations. Conclusions These histopathological and biochemical findings show the beneficial effects of apocynin on testicular ischemia-reperfusion injury.en_US
dc.identifier.citationÖzbek, Ö. Altıntaş, R. Polat, A. Vardı, N. Parlakpınar, H. Sağır, M. Duran, Z. R. Yıldız, A. (2015). The Protective Effect of Apocynin on Testicular Ischemia Reperfusion Injury. The Journal of Urology, 193(4), 1417–1422.en_US
dc.identifier.doi10.1016/j.juro.2014.11.086en_US
dc.identifier.endpage1422en_US
dc.identifier.issn00225347
dc.identifier.issue4en_US
dc.identifier.startpage1417en_US
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0022534714049349
dc.identifier.urihttps://hdl.handle.net/11616/6632
dc.identifier.volume193en_US
dc.language.isoenen_US
dc.publisherThe journal of ürologyen_US
dc.relation.ispartofThe journal of ürologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectTestisen_US
dc.subjectSpermatic cord torsionen_US
dc.subjectReperfusion injuryen_US
dc.subjectAcetovanilloneen_US
dc.subjectAntioxidantsen_US
dc.titleThe protective effect of apocynin on testicular ischemia reperfusion injuryen_US
dc.typeArticleen_US

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