Karaciğer nakli alıcılarında herpes simpleks virüs viremisinin tanısı, klinik görünümleri ve tedavi yönetimi

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dc.contributor.authorKöse, Adem
dc.contributor.authorToplu, Sibel
dc.contributor.authorGönültaş, Fatih
dc.contributor.authorKoç, Cemalettin
dc.contributor.authorYakupoğulları, Yusuf
dc.contributor.authorOtlu, Barış
dc.contributor.authorŞamdancı, Emine Türkmen
dc.date.accessioned2024-08-04T19:54:38Z
dc.date.available2024-08-04T19:54:38Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: We aimed to evaluate the clinical variations, possible risk factors and results of diagnostic procedures in liver transplant (LT) recipients who suffered from Herpes Simplex Virus (HSV) viremia in the post-transplant period, despite Cytomegalovirus (CMV) prophylaxis. Material and methods: The data of 1100 LT recipients were evaluated retrospectively. HSV DNA RT-PCR detected in blood and vesicular fluid samples of the patients with active painful mucocutaneous vesicular lesions and patients with organ involvement who had biopsy and confirmed HSV viremia were included in the study. The 110 recipients diagnosed with HSV viremia were included. Results: In 110 recipients, total 130 HSV viremia episodes were observed over sixty months. HSV viremia rate was 11.8%. Of the 130 HSV episodes, 120 (92.3%) were mucocutaneous form of the disease. In 10 cases, there was a specific organ involvement. HSV-1 was detected in all of viremia episodes. Sixty-four (49.2%) episodes developed six months after the LT, 41 (31.5%) episodes developed between the 1st and 6th months after LT, and 25 (20.3%) episodes were observed within the first postoperative month. All episodes were treated successfully with different antiviral therapy modalities. Conclusion: Despite CMV prophylaxis performed, HSV viremia may be occurred as a wide range of clinical presentation in LT recipients. It can be seen at any time point after the LT. HSV DNA RT-PCR from serum samples may not be sufficient for diagnosis of viremia, therefore the analysis of the vesicular fluid or the biopsy from the organs may be necessary for supporting the diagnosis.en_US
dc.identifier.doi10.18663/tjcl.954392
dc.identifier.endpage272en_US
dc.identifier.issn2149-8296
dc.identifier.issue3en_US
dc.identifier.startpage265en_US
dc.identifier.trdizinid1114355en_US
dc.identifier.urihttps://doi.org/10.18663/tjcl.954392
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1114355
dc.identifier.urihttps://hdl.handle.net/11616/89976
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Clinics and Laboratoryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleKaraciğer nakli alıcılarında herpes simpleks virüs viremisinin tanısı, klinik görünümleri ve tedavi yönetimien_US
dc.typeArticleen_US

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