Effect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomy

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorKirimlioglu, V
dc.contributor.authorKirimlioglu, H
dc.contributor.authorYilmaz, S
dc.contributor.authorOzgor, D
dc.contributor.authorCoban, S
dc.contributor.authorKaradag, N
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description8th Meeting of the Turkish-Transplantation-Society -- JUN 22-24, 2005 -- Ankara, TURKEYen_US
dc.description.abstractThe high capacity of liver regeneration after partial hepatectomy (PH) is well known. This study investigated the role of the antioxidant defense system in regeneration among Wistar-albino male rats subjected to 70% partial hepatectomy after a pretreatment period of 2 weeks with eicosapentanoic acid (EPA) rich fish oil (FO), first pressed virgin olive oil (00), or vitamin E. The control group of 10 rats underwent PH only. On postoperative day 3, all rats were humanely killed. Liver sections of animals treated with FO or vitamin E showed significant increases in regeneration within both liver parenchyma and cut surface compared with the control group (P < .05). Liver sections of 00 displayed an insignificant increase in liver regeneration (P > .05), with less increase in parenchyma than of the cut surface. The enhancement of the liver parenchymal regeneration in the FO group was significantly greater than that of the vitamin E group. Concerning liver function tests (LIFT), there was no significant difference among the groups. When the treatment groups were compared to the control group glutathione (GSH) levels were increased and content of malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) were decreased. Based on these results, we concluded that after 70% PH in rats, the liver parenchyma and cut surface regeneration were greatest with FO and least with 00 treatment. Both FO and vitamin E served to improve the antioxidant defense system more than 00 treatment.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2006.02.005
dc.identifier.endpage567en_US
dc.identifier.issn0041-1345
dc.identifier.issue2en_US
dc.identifier.pmid16549176en_US
dc.identifier.scopus2-s2.0-33645104043en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage564en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2006.02.005
dc.identifier.urihttps://hdl.handle.net/11616/94321
dc.identifier.volume38en_US
dc.identifier.wosWOS:000236440100060en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRegenerationen_US
dc.subjectNutritionen_US
dc.titleEffect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomyen_US
dc.typeConference Objecten_US

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