Factors effecting the development of sentinel lymph node metastasis in clinical early-stage breast cancers (cT1-2N0): Clinical significance of primary tumor – skin distance
| dc.contributor.author | Zirek, Levent | |
| dc.contributor.author | Lale, Azmi | |
| dc.contributor.author | Zirek, Merve | |
| dc.contributor.author | Lale, Hatice Nur | |
| dc.contributor.author | Yildirir, Ali Cihan | |
| dc.contributor.author | Aygen, Erhan | |
| dc.date.accessioned | 2022-03-15T09:34:30Z | |
| dc.date.available | 2022-03-15T09:34:30Z | |
| dc.date.issued | 2021 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: It was aimed to determine the demographic, clinicopathological and radiological predictors that may be effective in the development of sentinel lymph node (SLN) metastasis in patients with clinical early-stage breast cancer (cT1-2N0). Materials and Methods: 178 patients were included in the study. Demographic, clinicopathological and radiological characteristics of the patients were recorded. Among these, there were age, neutrophil / lymphocyte ratio (NLR), HER2, estrogen receptor (ER) and progesterone receptor (PR), proliferation index (Ki- 67), morphological grade, molecular subtype, histopathological subtype, tumor size and localization, multifocality and multicentricity, nipple-areola complex (NAC) infiltration, perineural invasion (PNI), lymphatic invasion (LI), vascular invasion (VI), primary tumor -breast skin distance (DFS). Results: Larger tumor size, HER-2 positivity, grade 3 histopathology, LI, VI, PNI, and closer DFS were found to be significant in univariate regression analyzes. In ROC analysis, the optimum cut-off value for DFS was found to be 13.5mm. In multivariant regression analyzes, HER-2 positivity, LI, PNI and ≤13.5mm DFS were found as independent SLN metastasis predictors. Conclusion: Closer DFS, HER-2 positivity, LI and PNI are very strong predictors in patients with clinical early-stage breast cancer that must be taken into account in the development of SLN metastasis in cT1-2N0 breast cancers. These factors can guide clinicians to take accurate decisions in the treatment process. | en_US |
| dc.identifier.citation | Zirek, L., Lale, A., Zirek, M., Lale, H. N., Yildirir, A. C., & Aygen, E. (2021). Factors effecting the development of sentinel lymph node metastasis in clinical early-stage breast cancers (cT1-2N0): Clinical significance of primary tumor – skin distance. Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/55616 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Factors effecting the development of sentinel lymph node metastasis in clinical early-stage breast cancers (cT1-2N0): Clinical significance of primary tumor – skin distance | en_US |
| dc.type | Article | en_US |
