Does Quercetin Supplementation Promote Biological Changes and Performance in Athletes? A Systematic Review

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dc.contributor.authorFernandes, Matheus Santos de Sousa
dc.contributor.authorFerreira, Diorginis José Soares
dc.contributor.authorYagin, Fatma Hilal
dc.contributor.authorBadicu, Georgian
dc.contributor.authorSilva, Clarice Beatriz Gonçalves
dc.contributor.authorCosta, Jonathan Manoel da
dc.contributor.authorSantos, Gabriela Carvalho Jurema
dc.date.accessioned2026-04-04T13:19:02Z
dc.date.available2026-04-04T13:19:02Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Summarize the available evidence in the literature regarding the repercussions generated by quercetin supplementation in amateur and professional athletes. Methods: Searches were conducted in four databases, Cochrane Library (23 articles), PubMed/Medline (37 articles), Scopus (70 articles), and Excerpta Medica Database (EMBASE) (72 articles), which were subjected to eligibility criteria. Results: Out of 202 articles found, 95 duplicates were removed, and 107 articles were analyzed for the inclusion process. Then, 784 studies were excluded after title/abstract evaluation, resulting in 17 articles of which 13 were included in this systematic review. After quercetin supplementation, alterations in aspects related to the inflammatory response were observed, mainly through modifications in the formation of interleukin (IL)-1β, interleukin 2 (IL-2), interleukin 8 (IL-8), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor alpha (TNF-α). Responses were also observed in biochemical parameters, such as reduction of xanthine oxidase, and plasma free radicals. There were also changes related to anthropometry and body composition, in lean body mass (LBM). Some repercussions on performance were also observed, such as an increase in Sprint time (s), and training efficacy, a decrease post-run muscular pain through the Visual Analog Score (VAS), and recovery time in hours. Conclusion: This systematic review indicates that quercetin supplementation does not improve exercise performance, but may exert positive effects on training development, which might trigger better performance as training progresses. On the inflammatory and oxidative-related parameters, just a few evidence pointed to an improved biochemical profile, wherein the slight enhancement may not justify the supplementation costs. © 2024 The Author(s).
dc.description.sponsorshipKing Khalid University, KKU, (RGP2/216/45); King Khalid University, KKU
dc.identifier.doi10.23812/j.biol.regul.homeost.agents.20243807.430
dc.identifier.endpage5381
dc.identifier.issn0393-974X
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85201073332
dc.identifier.scopusqualityN/A
dc.identifier.startpage5371
dc.identifier.urihttps://doi.org/10.23812/j.biol.regul.homeost.agents.20243807.430
dc.identifier.urihttps://hdl.handle.net/11616/108108
dc.identifier.volume38
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBiolife Publisher
dc.relation.ispartofJournal of Biological Regulators and Homeostatic Agents
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectathletes
dc.subjectperformance
dc.subjectphysical activity
dc.subjectquercetin
dc.subjectsports nutrition
dc.titleDoes Quercetin Supplementation Promote Biological Changes and Performance in Athletes? A Systematic Review
dc.typeArticle

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