Single Input Multi Output Model of Molecular Communication via Diffusion With Spheroidal Receivers

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dc.contributor.authorIsik, Ibrahim
dc.contributor.authorRezaei, Mitra
dc.contributor.authorNoel, Adam
dc.date.accessioned2026-04-04T13:33:23Z
dc.date.available2026-04-04T13:33:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractSpheroids are aggregates of cells that can mimic the cellular organization often found in tissues. Spheroids can be created from various cell types, including cancer cells, stem cells, and primary cells, and they serve as valuable tools in biological research. Although there are initial results on how a molecular signal can propagate between a pair of spheroids, practical experiments typically use clusters of spheroids and there isn't a good understanding of how neighboring spheroids impact the spatiotemporal dynamics of local molecule propagation. This paper simulates a series of scenarios to gain intuition about propagation in such multi-spheroid systems for applications such as transport and drug delivery. The spheroids are modeled as porous media with a corresponding effective diffusion coefficient. System variations are considered with a higher spheroid porosity (i.e., with a higher effective diffusion coefficient) and molecule uptake by the spheroid cells (approximated as a first-order degradation reaction while molecules diffuse within the spheroid). Results show that a local crowd of spheroids will eventually slow overall propagation, such that molecules stay in the vicinity of the transmitter for longer. The results demonstrate that a single-spheroid receiver model is insufficient to accurately model propagation under these conditions.
dc.description.sponsorshipEngineering and Physical Sciences Research Council [EP/V030493/1]
dc.description.sponsorshipThis work was supported by the Engineering and Physical Sciences Research Council under Grant EP/V030493/1.
dc.identifier.doi10.1109/TMBMC.2024.3521984
dc.identifier.endpage106
dc.identifier.issn2332-7804
dc.identifier.issue1
dc.identifier.orcid0000-0001-5826-3856
dc.identifier.orcid0000-0003-1355-9420
dc.identifier.orcid0000-0003-0508-6467
dc.identifier.scopus2-s2.0-105003043581
dc.identifier.scopusqualityQ2
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1109/TMBMC.2024.3521984
dc.identifier.urihttps://hdl.handle.net/11616/109123
dc.identifier.volume11
dc.identifier.wosWOS:001447544200010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIeee-Inst Electrical Electronics Engineers Inc
dc.relation.ispartofIEEE Transactions on Molecular Biological and Multi-Scale Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectReceivers
dc.subjectMathematical models
dc.subjectMolecular communication
dc.subjectBiological system modeling
dc.subjectDrugs
dc.subjectTransmitters
dc.subjectThree-dimensional displays
dc.subjectTumors
dc.subjectNanobioscience
dc.subjectFluids
dc.subjectSIMO
dc.subjectspheroidal receiver
dc.subjectconcentration
dc.subjectorgan-on-chip
dc.titleSingle Input Multi Output Model of Molecular Communication via Diffusion With Spheroidal Receivers
dc.typeArticle

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