Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes

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dc.authoridAKTAŞ, SERDAR/0000-0003-3243-8093
dc.authoridSÜZEN, ALEV/0000-0002-0595-3308
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authorwosidAKTAŞ, SERDAR/KCY-7784-2024
dc.authorwosidSÜZEN, ALEV/AAB-9317-2019
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.contributor.authorSuzen, Alev
dc.contributor.authorTekin, Leyla
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorErturk, Nazile
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorAktas, Serdar
dc.date.accessioned2024-08-04T20:43:58Z
dc.date.available2024-08-04T20:43:58Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose This study aimed to compare the protective effects of Hypericum perforatum (Hp) and quercetin, a flavonoid, against ischemia/reperfusion (I/R) injury in rat testes. Materials and Methods This study included 28 male Wistar albino rats that were divided into four groups. Except for the sham group, torsion was created by rotating both testes at an angle of 720 degrees clockwise for 2 hours. The Hp and quercetin groups received 25 mg/kg Hp and quercetin intraperitoneally 30 minutes before detorsion, respectively. Orchiectomy was performed for the measurement of markers of oxidative stress and histopathological examination. Results In the Hp and quercetin groups, malondialdehyde (MDA) and nitric oxide (NO) levels and total oxidant capacity were significantly lower, the glutathione level and total antioxidant status were significantly higher, and Johnsen's testis biopsy scores were significantly higher than in the torsion/detorsion group (p=0.001). The markers of oxidative injury were significantly lower (p=0.001) and total antioxidant status was significantly higher (p=0.001), except for glutathione (p=0.62) in the Hp group than in the quercetin group. Johnsen's score between Hp and quercetin groups was not significantly different (p=0.80). Conclusion Both Hp and quercetin have protective effects against I/R injury of the testes, but the protective effect of Hp was found to be stronger than that of quercetin.en_US
dc.identifier.doi10.1055/s-0037-1604397
dc.identifier.endpage100en_US
dc.identifier.issn0939-7248
dc.identifier.issn1439-359X
dc.identifier.issue1en_US
dc.identifier.pmid28837999en_US
dc.identifier.scopus2-s2.0-85028341904en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.1055/s-0037-1604397
dc.identifier.urihttps://hdl.handle.net/11616/97948
dc.identifier.volume28en_US
dc.identifier.wosWOS:000422934200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttestis torsionen_US
dc.subjectHypericum perforatumen_US
dc.subjectquercetinen_US
dc.titleProtective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testesen_US
dc.typeArticleen_US

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