Protective Effects of Melatonin and Aminoguanidine on the Cornea in Streptozotocin-induced Diabetic Rats

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridEmre, Sinan/0000-0002-9788-3895
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidEmre, Sinan/T-5643-2019
dc.contributor.authorGul, Mehmet
dc.contributor.authorEmre, Sinan
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This study was designed to investigate the protective effect of aminoguanidine (AG) and melatonin (M) on the cornea in a streptozotocin-induced diabetic rat model. Methods: Twenty-eight Sprague-Dawley rats were used in this study. Animals were divided into 4 groups: control (C), diabetes (D), diabetes + AG (D+AG), and diabetes + M (D+M). Diabetes was induced by 1 intraperitoneal dose of 45 mg/kg of streptozotocin (STZ). In the treatment groups, the D + AG group received AG in their water (1 g/L), and D + M rats were injected with M (10 mg/kg/d) intraperitoneally. One of the groups remained an untreated diabetic group (D group). All animals were euthanized at the end of 8 weeks. After enucleation, eyes were fixed in 10% phosphate-buffered formalin and embedded in paraffin wax. Histochemical stains were applied, and specimens were examined under a light microscope. Results: After 8 weeks, the rats in the diabetes group had significantly lower body weight and significantly higher blood glucose levels than those of the control, D + AG, and D + M groups. Diabetes resulted in prominent edema in the stroma with interruptions in the subepithelial basement membrane. These alterations were not prominent or were absent in the D + AG and D + M groups. The mean thicknesses of the cornea, corneal epithelium, and stroma were statistically significantly different between the C and D, and D and D + AG and D + M groups (P < 0.05). Conclusions: Long-term administration of AG and M reduced corneal injury in an STZ-induced diabetic rat model. AG and M may be potential candidates in the treatment of diabetic keratopathies. However, further studies are needed to elucidate the mechanisms of the protective effect of both molecules on diabetic corneal complications.en_US
dc.identifier.endpage801en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue7en_US
dc.identifier.pmid18650666en_US
dc.identifier.scopus2-s2.0-49849102472en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage795en_US
dc.identifier.urihttps://hdl.handle.net/11616/94629
dc.identifier.volume27en_US
dc.identifier.wosWOS:000260055700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminoguanidineen_US
dc.subjectcorneaen_US
dc.subjectmelatoninen_US
dc.subjectstreptozotocin-induced diabetes mellitusen_US
dc.titleProtective Effects of Melatonin and Aminoguanidine on the Cornea in Streptozotocin-induced Diabetic Ratsen_US
dc.typeArticleen_US

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