Effects of Perineural Administration of Dexmedetomidine in Combination with Levobupivacaine in a Rat Sciatic Nerve Block

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dc.authorscopusid55178121700
dc.authorscopusid11738762300
dc.authorscopusid7005217039
dc.authorscopusid47460989500
dc.authorscopusid6602664864
dc.authorscopusid55775592400
dc.authorscopusid34569135700
dc.contributor.authorAli Erdogan M.
dc.contributor.authorPolat A.
dc.contributor.authorYucel A.
dc.contributor.authorAydogan M.S.
dc.contributor.authorParlakpinar H.
dc.contributor.authorTekin S.
dc.contributor.authorDurmus M.
dc.date.accessioned2024-08-04T19:59:06Z
dc.date.available2024-08-04T19:59:06Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to assess if perineural administration of dexmedetomidine combined with levobupivacaine increases the duration of the sensory and motor blockade of a sciatic peripheral nerve block in rats. Methods: Forty male Sprague-Dawley rats were randomly divided into 5 experimental groups: Group 1, sham; Group 2, perineural levobupivacaine (0.2 mL of a 0.5% solution) and subcutaneous saline; Group 3, perineural levobupivacaine (0.2 mL of a 0.5% solution) plus dexmedetomidine (20 ?g/kg dexmedetomidine) and subcutaneous saline; Group 4, perineural saline and subcutaneous dexmedetomidine; and Group 5, perineural saline and subcutaneous saline. Pain reflexes in response to a thermal stimulus were measured at 0 and 240 minutes after drug administration by using a hot-plate and tail-flick tests. Neurobehavioral status, including sensory and motor functions, was assessed by an investigator who was blinded to the experimental groups every 30 minutes until normal functioning resumed. Results: The sensory and motor blockades of the rats did not increase in the treatment with dexmedetomidine plus levobupivacaine when compared with the treatment with levobupivacaine alone at all the time points ( P > 0.05). Compared with rats in Group 2, those in Group 3 showed significantly higher latency times at 30 and 60 minutes in the hot plate test ( P < 0.01). At 30 and 60 minutes, the latency times of the rats in Group 3 were longer than those in Group 2 in the tail-flick test ( P < 0.01). Furthermore, the durations of the complete sensory and motor blockade were similar when treatment with levobupivacaine plus dexmedetomidine was compared with treatment with levobupivacaine alone. Conclusions: A 20?g/kg dose of dexmedetomidine added to levobupivacaine did not increase the duration of the sensory and motor blockades in rats. However, treatment with dexmedetomidine plus levobupivacaine increased the quality of analgesia in rats. © 2013 The Authors.en_US
dc.description.sponsorship2011/94en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific Research Fund of Inonu University (No. 2011/94). All authors contributed equally to the creation of this manuscript.en_US
dc.identifier.doi10.1016/j.curtheres.2013.03.001
dc.identifier.endpage78en_US
dc.identifier.issn0011-393X
dc.identifier.scopus2-s2.0-84879429698en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2013.03.001
dc.identifier.urihttps://hdl.handle.net/11616/90384
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Therapeutic Research - Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnesthesia adjuvantsen_US
dc.subjectDexmedetomidineen_US
dc.subjectLevobupivacaineen_US
dc.subjectNerve blocken_US
dc.subjectSciatic nerveen_US
dc.titleEffects of Perineural Administration of Dexmedetomidine in Combination with Levobupivacaine in a Rat Sciatic Nerve Blocken_US
dc.typeArticleen_US

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