Koroner ektazisi olan hastalarda aortun elastik özellikleri ile serum yüksek duyarlılıklı C-reaktif protein arasındaki ilişkinin değerlendirilmesi
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Anadolu Kardiyoloji Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Amaç: Daha önceki çalışmalar, kardiyovasküler hastalıklar ile arteryel sertlik ve yüksek duyarlı C-reaktif protein (hsCRP) arasındaki ilişkiyi göstermektedir. Serum hsCRP ve arteryel sertlik, kardiyovasküler hastalıklara bağlı mortalitenin bağımsız prediktörleri olarak düşünülmektedir. Çalışmamızın amacı koroner ektazisi (KAE) olan hastalarda aortik sertlik ile enflamatuvar marker olan hsCRP arasındaki ilişkiyi araştırmaktı. Yöntemler: Çalışmamız enine kesitsel olarak dizayn edildi. Serum hsCRP seviyeleri ve aortik sertlik parametreleri, aynı yaş ve cinsiyette olan 28 koroner ektazili hasta ve 25 kontrol grubunda karşılaştırıldı. Serum hsCRP seviyeleri, immünonefelometrik analiz yöntemiyle ölçüldü. Aortik gerilim (AG) ve aortik distensibilite (AD) sfigmomanometre ile ölçülen kan basınçları ve M-mod ekokardiyografi kullanılarak ölçülen aortik çaplardan hesaplandı.İstatistiksel analizde bağımsız örneklem t-testi, Ki-kare testi ve Spearman korelasyon testi kullanıldı. Bulgular: Koroner arter ektazisi (KAE) grubunda serum hsCRP seviyeleri kontrol grubundan daha yüksekti (p<0.001). Aortik gerilim (AG) ve AD kontrol grubuna göre KAE’li hastalarda anlamlı olarak düşüktü (sırasıyla, p<0.001 ve p<0.001). Aortik sertlik indeks ve hsCRP arasında pozitif korelasyon (r=0.852; p<0.001) ve AD (r=-0.852; p<0.001) ve AS (r=-0.862; p<0.001) ile hsCRP arasında negatif korelasyon vardı. Sonuç: Biz koroner ektazili hastalarda aortik sertlik ve serum hsCRP seviyeleri arasında önemli korelasyon olduğunu gösterdik. Bu bulgular koroner ektazide bozulmuş aortik sertlik patogenezinde hsCRP’nin önemli rolü olduğunu göstermektedir.
Abstract: Objective: Previous studies have shown an association between high sensitive C-reactive protein (hsCRP) and arterial stiffness in most cardiovascular diseases. High sensitive C-reactive protein and arterial stiffness have been considered as independent predictors of cardiovascular mortality in cardiovascular disease. The aim of this study was to investigate the relationship between hsCRP, a marker of systemic inflammation and aortic stiffness in patients with coronary artery ectasia (CAE). Methods: Our study was designed as cross-sectional study. Serum hsCRP levels and aortic stiffness parameters were measured in CAE patients (n=28) and age - and gender-matched control subjects (n=25). Serum hsCRP levels were determined by an immunonephelometry assay. Aortic strain (AS) and aortic distensibility (AD) were calculated from the aortic diameters measured using M-mode echocardiography and blood pressure obtained by sphygmomanometry. Independent samples &#8220;t&#8221; test, Chi-square test and Spearman correlation test were used for statistical analysis. Results: Serum levels of hsCRP in CAE group were higher than in the controls (p<0.001). AS and AD were significantly decreased in CAE patients compared to the controls (p<0.001 and p<0.001, respectively). There were negative correlations between hsCRP and AS (r=-0.862; p<0.001), and AD (r=0.852; p<0.001) and a positive correlation between hsCRP, and ASI (r=0.852; p<0.001). Conclusion: We have demonstrated that there is a significant correlation between serum hsCRP levels and aortic stiffness in patients with CAE. These findings may indicate an important role of hsCRP in the pathogenesis of impaired aortic stiffness in coronary ectasia.
Abstract: Objective: Previous studies have shown an association between high sensitive C-reactive protein (hsCRP) and arterial stiffness in most cardiovascular diseases. High sensitive C-reactive protein and arterial stiffness have been considered as independent predictors of cardiovascular mortality in cardiovascular disease. The aim of this study was to investigate the relationship between hsCRP, a marker of systemic inflammation and aortic stiffness in patients with coronary artery ectasia (CAE). Methods: Our study was designed as cross-sectional study. Serum hsCRP levels and aortic stiffness parameters were measured in CAE patients (n=28) and age - and gender-matched control subjects (n=25). Serum hsCRP levels were determined by an immunonephelometry assay. Aortic strain (AS) and aortic distensibility (AD) were calculated from the aortic diameters measured using M-mode echocardiography and blood pressure obtained by sphygmomanometry. Independent samples &#8220;t&#8221; test, Chi-square test and Spearman correlation test were used for statistical analysis. Results: Serum levels of hsCRP in CAE group were higher than in the controls (p<0.001). AS and AD were significantly decreased in CAE patients compared to the controls (p<0.001 and p<0.001, respectively). There were negative correlations between hsCRP and AS (r=-0.862; p<0.001), and AD (r=0.852; p<0.001) and a positive correlation between hsCRP, and ASI (r=0.852; p<0.001). Conclusion: We have demonstrated that there is a significant correlation between serum hsCRP levels and aortic stiffness in patients with CAE. These findings may indicate an important role of hsCRP in the pathogenesis of impaired aortic stiffness in coronary ectasia.
Açıklama
Anahtar Kelimeler
Kaynak
Anadolu Kardiyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
5
Künye
SİNCER İ,AKTÜRK E,AÇIKGÖZ N,ERMİŞ N,FERİDUN M. K (2011). Koroner ektazisi olan hastalarda aortun elastik özellikleri ile serum yüksek duyarlılıklı C-reaktif protein arasındaki ilişkinin değerlendirilmesi. Anadolu Kardiyoloji Dergisi, 11(5), 414 - 420.
