Alpha lipoic acid decreases neuronal damage on brain tissue of STZ-induced diabetic rats

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridYilmaz, Nesibe/0000-0002-5527-8507
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidYilmaz, Nesibe/JFK-5834-2023
dc.contributor.authorTanbek, Kevser
dc.contributor.authorOzerol, Elif
dc.contributor.authorYilmaz, Umit
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorGul, Mehmet
dc.contributor.authorColak, Cemil
dc.date.accessioned2024-08-04T20:51:40Z
dc.date.available2024-08-04T20:51:40Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNeuropathy that develops due to diabetic complications causes cognitive impairment due to functional and structural damage. The aim of this study was to evaluate the biochemical, histological and physiological effects of Alpha Lipoic Acid (ALA) against brain tissue damage caused by diabetes. Fourty male Wistar albino rats were separated into four groups as control, diabetes mellitus (DM), ALA and DM+ALA. Single dose of 50 mg/kg intraperitonal streptozotocin (STZ) was used to induce DM. For six weeks, ALA (100 mg/kg/day) was administered to the ALA and DM+ALA groups. At the end of the six week rats were sacrificed by collecting blood samples and collected brain tissues (hippocampus, cortex, hippotalamus and striatum) were histologically evaluated in addition to the oxidant-antioxidant parameters. ALA administration showed significant improvement in cognitive functions evaluated by MWM in rats with diabetes mellitus (p < 0.05). SOD, CAT, GSH-Px activities, which were decreased in the DM group compared to the control group, increased statistically significantly in rats in DM+ALA group (p < 0.05). While MDA and PC levels increased in the DM group, they decreased statistically significantly in the DM+ALA group (p < 0.05). According to the histological examinations made by light and electron microscopies, it was determined that the ultrastructural damage and degeneration findings observed in the sections of the DM group were significantly ameliorated in the sections of rats in the DM+ALA group. ALA may be effective in restoring cell damage and cognitive functions in brain tissue with its antioxidant and neuroprotective effects without showing antidiabetic effects.en_US
dc.description.sponsorshipResearch Support Unit of Inonu University [2016/38]en_US
dc.description.sponsorshipThis work was supported by the The Research Support Unit of Inonu University (project number 2016/38) .en_US
dc.identifier.doi10.1016/j.physbeh.2022.113727
dc.identifier.issn0031-9384
dc.identifier.issn1873-507X
dc.identifier.pmid35131301en_US
dc.identifier.scopus2-s2.0-85124556689en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2022.113727
dc.identifier.urihttps://hdl.handle.net/11616/100482
dc.identifier.volume248en_US
dc.identifier.wosWOS:000779421300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhysiology & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectNeuropathyen_US
dc.subjectBrainen_US
dc.subjectCognitive functionsen_US
dc.titleAlpha lipoic acid decreases neuronal damage on brain tissue of STZ-induced diabetic ratsen_US
dc.typeArticleen_US

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