Effects of pinealectomy and exogenous melatonin on rat hearts

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorMuzrak, B
dc.contributor.authorParlakpinar, H
dc.contributor.authorAcet, A
dc.contributor.authorTurkoz, Y
dc.date.accessioned2024-08-04T20:13:46Z
dc.date.available2024-08-04T20:13:46Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of pinealectomy and administration of melatonin, the major secretory product of the pineal gland, which is a direct free radical scavenger and an indirect antioxidant, were studied in rat hearts on the basis of cardiac morphology and biochemical findings. Three groups of Wistar rats were used: one group was the shamoperated control, one group consisted of pinealectomized rats and one group consisted of pinealectomized rats that were treated with melatonin. Serum cholesterol, tissue levels of malondialdehyde (MDA) and reduced glutathione (GSH), and heart weight were determined. Histochemical staining with the Van Gieson, PAS/ Alcian blue at pH 2.5 and Masson's trichrome methods were performed in addition to hematoxylin-eosin staining. Levels of serum cholesterol and tissue MDA, and heart weight were increased in pinealectomized rats whereas GSH levels did not change. Melatonin administration reversed these effects. Microscopically, myocardial fibrosis and myxomatous degeneration of cardiac valves were detected in all pinealectomized rats. It can be concluded that pineatectomy of rats causes morphological changes in rat hearts, and short-term application of metatonin does not reverse these changes. (C) 2003 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2003.10.003
dc.identifier.endpage36en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue1en_US
dc.identifier.pmid15032326en_US
dc.identifier.scopus2-s2.0-1442349717en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2003.10.003
dc.identifier.urihttps://hdl.handle.net/11616/93823
dc.identifier.volume106en_US
dc.identifier.wosWOS:000220401100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectraten_US
dc.subjecthearten_US
dc.subjectmyxomatous degenerationen_US
dc.titleEffects of pinealectomy and exogenous melatonin on rat heartsen_US
dc.typeArticleen_US

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