Central irisin administration suppresses thyroid hormone production but increases energyconsumption in rats
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevıer ıreland ltd, elsevıer house, brookvale plaza, east park shannon, co, clare, 00000, ıreland
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Irisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones.
Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded.
Food intake was significantly increased in the groups treated with irisin (p < 0.05), but their body weights were not changed. Hypothalamic TRH gene expression, serum TSH, fT3, and fT4 levels were significantly lower in the groups treated with irisin as compared to the naive and control groups (p < 0.05). In addition, irisin increased UCP1 mRNA expression in white and brown adipose tissue and UCP3 mRNA expression in muscle tissue in rats and also raised their body temperature (p < 0.05).
Consequently, although central irisin administration has inhibitory effects on the hypothalamic-pituitary thyroid axis, it seems to be an important agent in the regulation of food intake and energy metabolism.
Açıklama
Anahtar Kelimeler
Cırculatıng ırısın, food-ıntake, uncouplıng proteıns, feedıng-behavıor, adıpose-tıssue, obesıty, myokıne, muscle, expressıon, exercıse
Kaynak
Neuroscıence letters
WoS Q Değeri
Scopus Q Değeri
Cilt
674
Sayı
0
Künye
Tekin, S. Erden, Y. Ozyalin, F. Onalan, EE . Cigremis, Y. Colak, C. Tekedereli, I. Sandal, S.(2018). Central irisin administration suppresses thyroid hormone production but increases energyconsumption in rats. Cilt:674. 136-141 ss.
