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Öğe Lengths of the menstrual cycle and menstruation are positively correlated with general tiredness in long-term entrained students(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2017) Uğraş, S.; Uçar, C.; Atcali, T.; Yıldız, S.Öğe Apc gene expression levels in tumor and adjacent normal tissues of colorectal cancer patients(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2017) Yilmaz, Nesibe; Yilmaz, Umit; Ergen, Arzu; Aksakal, Nihat; Zeybek, UmitÖğe Analysis of relationship between dioxin-like and estrogenic bioactivity and genotoxic changes inmammary epithelial cells with nutritional habits of breastfeeding mothers(Rıver st, hoboken 07030-5774, nj usa wıley, 111, 2017) Agus, Sami; Atasayan, Ozge; Sandal, Suleyman; Mete, Fatih; Eyuboglu, Signem; Yilmaz, BayramÖğe Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats(WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018) Kalkan, Ferhat; Parlakpinar, Hakan; Disli, Olcay M.; Tanriverdi, Lokman H.; Ozhan, Onural; Polat, Alaaddin; Cetin, Asli; Vardi, Nigar; Otlu, Yilmaz O.; Acet, AhmetThe purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24h; group III (DEX+ISO): DEX (250mg/kg) was applied 30min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO2), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO2 values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.Öğe Thrombocytapheresis decreases systolic blood pressure and increasessympatho-vagal balance(Pergamon-elsevıer scıence ltd, the boulevard, langford lane, kıdlıngton, oxford ox5 1gb, england, 2018) Cakan, P.; Ozgul, M.; Erkurt, M.; Kaya, E.; Yildiz, S.; Kuku, I.Öğe New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies(ELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLAND, 2018) Tekin, SuatA new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L)(2)] and [Pt(L)(2)), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules. The photophysical properties changes were observed after deprotonation of L with CN- via intermolecular charge transfer (ICT). Additionally, as the sensor is a colorimetric and fluorimetric cyanide probe containing active sites such as coumarin-thiazole and imine (CH = N), it showed fast color change from yellow to deep red in the visible region, and yellow fluorescence after CN- addition to the imine bond, in DMSO. The reaction mechanisms of L with CN-, F- and AcO- ions were evaluated using H-1 NMR shifts. The results showed that, the reaction of L with CN- ion was due to the deprotonation and addition mechanisms at the same time. The anti-cancer activity of L and its Pd(II) and Pt(II) complexes were evaluated in vitro using MTT assay on the human cancer lines MCF-7 (human breast adenocarcinoma), LS174T (human colon carcinoma), and LNCAP (human prostate adenocarcinoma). The anticancer effects of L and its complexes, on human cells, were determined by comparing the half maximal inhibitory concentration (IC50) values. The activity results showed that, the Pd(II) complex of L has higher antitumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.Öğe Mots-c ıncreases food consumption of rats but does not alter body weight(KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND, 2018) Beytur, Asiye; Tekin, Suat; Sandal, SüleymanÖğe Pinealectomy alters ıfn-gamma and ıl-10 levels in primary thymocyte culture of rats(C m b assoc, 34 boulevard solferıno, 86000 poıtıers, france, 2018) Sahin, Zafer; Sandal, Suleyman; Yilmaz, Bayram; Bulmus, Ozgur; Ozdemir, Gokcen; Kutlu, Selim; Godekmerdan, Ahmet; Kelestimur, HalukMelatonin, produced mainly by the pineal gland, has an immunomodulatory role. However, the effects of the pineal gland and/or melatonin on thymus cytokine levels such as interferon-gamma (IFN-gamma), interleukin (IL)-4, and IL-10 are not well known. Twenty-one male Wistar rats (220-250 gr) were randomly divided into three groups (n=7): intact control, sham, and pinealectomy. Primary thymocyte cultures were prepared from each group and dispensed into well plates as Control, DMSO (or vehicle), Sham-pinealectomy, Pinealectomy, Pinealectomy+10 mu M melatonin, and Pinealectomy+100 mu M melatonin. IFN-gamma, IL-4, and IL-10 concentrations were measured in the thymocytes (as nonstimulated and Concanavalin A-stimulated) after 24 h. IFN-gamma levels significantly increased and IL-10 levels significantly decreased in both media prepared from pinealectomized rats. There was no significant difference between the groups in terms of IL-4. In the pinealectomy+100 mu M melatonin group, IFN-gamma and IL-10 levels did not differ from the pinealectomy group. However, the dose of 100 mu M melatonin caused a decrease in levels of IFN-gamma in both thymocyte media and an increase in the concentration of IL-10 in Concanavalin A-stimulated thymocytes. In conclusion, pineal gland and or melatonin affect IFN-gamma and IL-10 levels in the thymus gland.Öğe Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from hypericum scabrum l. Flowers(Taylor and Francis Ltd., 2018) Keser, S.; Keser, F.; Kaygili, O.; Tekin, S.; Demir, E.; Turkoglu, I.; Turkoglu, S.; Parlak, A.E.Hypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determined. The water and ethanol extracts are better scavenged ABTS (97.89 and 98.99%) and OH radicals (96.36 and 97.33%); the water extract is better scavenged DPPH radicals (91.66%) than the standard antioxidant BHA (94.33, 85.19, 90.16%, respectively). Flowers of H. scabrum contain flavonoids, phenolic acids, vitamins and phytosterols, dominated by catechin, vanillic acid, vitamin K and ergosterol. The extracts exhibit a strong cytotoxic activity against MCF-7, HCT-116, and LNCaP cancer cell lines. It is found that their antimicrobial activities are higher than the standard antibiotics. These results indicate that H. scabrum flowers have potent antiradical, antimicrobial and cytotoxic activities. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.Öğe Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring(CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA, 2018) Çakan, Pınar; Yıldız, Sedat; Özgeçer, Tuba; Yıldız, Azibe; Vardi, NigarThis study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic-polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9-10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring.Öğe IL-1beta, IL-6 and TNF-alpha levels in women working under long-term (32-36 hour) shifts(PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, 2018) Çakan, Pınar; Yıldız, SedatÖğe Late-night exercise affects the autonomic nervous system activity but not the hypothalamo-pituitary-adrenal axis in the next morning(Edızıonı mınerva medıca, corso bramante 83-85 ınt journals dept., 10126 turın, ıtaly, 2018) Ucar, Cihat; Ozgocer, Tuba; Yildiz, SedatBACKGROUND: Exercise activates hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS) and generally causes beneficial changes in homeostatic balance. However, the health benefits of late-night exercise programs on the activity of HPA and ANS is not known. The aim of this study was to assess effects of late-night exercise on sleep quality and on the activities of the HPA axis (as cortisol awakening response, CAR) and the ANS (as heart rate variability, HRV) measurements in the following morning. METHODS: Medical students (N.=20 males, 20-24 years old) filled Karolinska Sleep Diary on the day before exercise program. In the following morning, they provided salivary samples for the assessment of CAR (samples at 0, 15, 30 and 60 min postawakening) and had a 5-min electrocardiogram recording for the determination of HRV. In the next night, an exercise program consisting of a 90-min football match was implemented at 09: 30 p.m. and all procedures were repeated. Cortisol concentrations were measured in the salivary samples and time-and frequency-domain parameters of HRV were calculated. RESULTS: Late-night exercise did not affect (P>0.05) sleep parameters (sleep duration, disturbed sleep, awakening problems) and CAR parameters (0, 15, 30, 60 min cortisol concentrations, mean concentration, area under the curve) but influenced HRV parameters (P<0.05). CONCLUSIONS: The results suggest that late-night exercise is associated with changed HRV activity rather than changes in CAR and, therefore, it might be suggested that late-night exercise affects ANS activity rather than HPA activity in the next morning.Öğe Effects of reciprocal interactions between various dietary fats and circadian phases on postprandial hyperlipidemia in rats(TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2018) Satılmış, Basri; Kayhan, Başak; Güldür, TayfunExpression levels of various intestinal proteins involved in postprandial lipoprotein assembly as well as plasma triglyceride concentration exhibit daily oscillations indicating circadian control. The length of the carbon chain and degree and position of unsaturation of fatty acids influence triglyceride secretion by the enterocytes. To this end, effects of reciprocal interactions of various single fats/oil (olive oil, fish oil or butter) gavaging either in active or passive phase were investigated in rats. Fat/oil gavaged in the active phase of circadian rhythm resulted in higher postprandial serum triglyceride levels compared to that in the passive phase. Moreover, olive oil led to higher MTP activity and apo B-48 gene expression, while fish oil gavaging caused more prominent apo B-48 and MTP gene expression when they were given in the passive phase. The present results indicate that circadian time at which fat or oil gavaged once might exert influence on postprandial lipoprotein synthesis/assembly.Öğe Effects of noopept on hippocampal ngf and bdnf levels and cognitive functions of prepubertalrats with streptozotocin-ınduced diabetes(KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND, 2018) Gürbüz, Perihan; Düzova, Halil; Kaya, Gül Büşra; Çakan, Pınar; Durhan, MerveÖğe Effect of increase in cortisol level due to stress in healthy young individuals on dynamic and staticbalance scores(Kare publ, concord ıstanbul, dumlupınar mah, cıhan sk no 15, b blok 162 kadıkoy, ıstanbul, 00000, turkey, 2018) Cay, Mahmut; Ucar, Cihat; Senol, Deniz; Cevirgen, Furkan; Ozbag, Davut; Altay, Zuhal; Yildiz, SedatOBJECTIVE: Stress is a condition caused by various factors and characterized by imbalance in body functioning, impair in nervous system, and tension. The purpose of this study was to examine the effects of cortisol level, which increases in healthy young individuals due to stress, on dynamic and static balance scores as well as to present the results caused by high levels of stress. METHODS: In this study, 107 healthy medicine faculty students in their second year (who will take the same committee exam) aged between 19 and 23 years were included. The first balance measurements and saliva samples were taken 40 days before the committee exam, and this period was acknowledged as the relaxed period. The same students were considered for balance measurements again on the day of committee exam; saliva samples were collected, and cortisol concentration was determined. This period was acknowledged as the stressful period. The State-Trait Anxiety Inventory (STAI) was given to the participants in their relaxed and stressful periods. Dynamic balance scores were measured with Star Excursion Balance Test (SEBT). Static balance scores were measured with One Leg Standing Balance Test (OLSBT). RESULTS: The mean cortisol level was found to increase approximately 9 times in stressful periods compared with that in relaxed periods. STAI, which shows state anxiety, showed an increase supporting this increase. In stressful periods, dynamic balance scores showed obvious decrease in all directions. In addition, in stressful periods, an obvious decrease was observed in static balance scores compared with those in relaxed periods. CONCLUSION: This study showed that stress negatively affected dynamic and static balance, even for short periods of time. We believe that our study will form a positive source and basis when correlated with long terms stress and balance measurements.Öğe Comparative evaluation of mda levels during aerobic exercise in young trainedand sedentary male subjects(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Algul, S.; Ugras, S.; Kara, M.The impacts of acute aerobic exercise on oxidative stress as determined altered MDA levels have been examined in young trained and sedentary male subjects. Total of 20 (10 trained and 10 sedentary) male subjects performed an aerobic cycling exercise at the anaerobic threshold for about 30 min. The venous blood samples (pre and post exercise) and analysed for MDA using HPLC methods. Wilcoxon and Mann Whitney U-tests were included in the statistical methods for data analysis. Acute exercise caused a systematic increase in MDA levels in trained (36.2%) and sedentary (55.4%) subjects during exercise (p<0.001). The increase in MDA levels were higher in sedentary subjects (0.79±0.08 µmol/L vs 1.02±0.05 µmol/L) compared to trained subjects (0.73±0.05 µmol/L vs 0.97±0.07 µmol/L) (p<0.001). Acute exercise may cause higher levels of increase in oxidative stress as determined alteration of MDA levels in sedentary subjects. Thus the sedentary subjects should pay more attention to the physical activities. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Central salusin-beta ınfusion ıncrease serum testosterone levels in male rats(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Tekin, Suat; Demir, Ilker; Sandal, SuleymanÖğe Central irisin administration suppresses thyroid hormone production but increases energyconsumption in rats(Elsevıer ıreland ltd, elsevıer house, brookvale plaza, east park shannon, co, clare, 00000, ıreland, 2018) Tekin, Suat; Erden, Yavuz; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, Cemil; Tekedereli, Ibrahim; Sandal, SuleymanIrisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded. Food intake was significantly increased in the groups treated with irisin (p < 0.05), but their body weights were not changed. Hypothalamic TRH gene expression, serum TSH, fT3, and fT4 levels were significantly lower in the groups treated with irisin as compared to the naive and control groups (p < 0.05). In addition, irisin increased UCP1 mRNA expression in white and brown adipose tissue and UCP3 mRNA expression in muscle tissue in rats and also raised their body temperature (p < 0.05). Consequently, although central irisin administration has inhibitory effects on the hypothalamic-pituitary thyroid axis, it seems to be an important agent in the regulation of food intake and energy metabolism.Öğe Cannabinoid type 2 receptors activation ımproves cognitive dysfunction in a okadaic acid ınducedalzheimer rat model(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Cakir, Murat; Tekin, SuatÖğe Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats(Journal of physıologıcal scıences, 2018) Yilmaz, Umit; Tekin, Suat; Demir, Mehmet; Cigremis, Yilmaz; Sandal, SuleymanThe aim of this study was to evaluate the impact of intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic-pituitary-thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used and divided into three groups including control, sham (vehicle) and FGF21 infused groups (n = 10). Intracerebroventricularly, FGF21 and vehicle groups were infused for 7 days with FGF21 (0.72 mu g/day) and artificial cerebrospinal fluid, respectively. During the experimental period, changes in food intake and body weight were recorded daily. Serum thyroid stimulating hormone (TSH), Triiodothyronine (T3) and thyroxine (T4) levels were measured using ELISA. TRH and uncoupling protein 1 (UCP1) gene expressions were analyzed by using RT-PCR in hypothalamus and adipose tissues, respectively. Chronic infusion of FGF21 significantly increased serum TSH (p < 0.05), T3 (p < 0.05) and T4 (p < 0.001) levels. Additionally, hypothalamic TRH (p < 0.05) and UCP1 gene expressions (p<0.05) in white adipose tissue were found to be higher than in the vehicle and control groups. While FGF21 infusion did not cause a significant change in food consumption, it caused a reduction in the body weight of rats (p < 0.05). Our findings indicate that FGF21 may have an effect on energy metabolism via the HPT axis.
