Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
This study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic-polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9-10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring.
Açıklama
Anahtar Kelimeler
Polyınosınıc-Polycytıdylıc Acıd, Immune Actıvatıon, Global Burden, Nıtrıc-Oxıde, Pharmacologıcal Changes, Influenza Infectıon, Braın Development, Lıfe-Hıstory, In-Utero, Schızophrenıa
Kaynak
Canadıan journal of physıology and pharmacology
WoS Q Değeri
Scopus Q Değeri
Cilt
96
Sayı
5
Künye
Çakan, P. Yıldız, S. Özgöçer, T. Yıldız, A. Vardi, N. (2018). Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring. Cilt:96 Sayı:5, 506-514 ss.
