Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring

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dc.contributor.authorÇakan, Pınar
dc.contributor.authorYıldız, Sedat
dc.contributor.authorÖzgeçer, Tuba
dc.contributor.authorYıldız, Azibe
dc.contributor.authorVardi, Nigar
dc.date.accessioned2019-07-18T11:56:19Z
dc.date.available2019-07-18T11:56:19Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic-polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9-10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring.en_US
dc.identifier.citationÇakan, P. Yıldız, S. Özgöçer, T. Yıldız, A. Vardi, N. (2018). Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring. Cilt:96 Sayı:5, 506-514 ss.en_US
dc.identifier.doi10.1139/cjpp-2016-0535en_US
dc.identifier.endpage514en_US
dc.identifier.issue5en_US
dc.identifier.startpage506en_US
dc.identifier.urihttps://hdl.handle.net/11616/12747
dc.identifier.volume96en_US
dc.language.isoenen_US
dc.publisherCANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADAen_US
dc.relation.ispartofCanadıan journal of physıology and pharmacologyen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectPolyınosınıc-Polycytıdylıc Acıden_US
dc.subjectImmune Actıvatıonen_US
dc.subjectGlobal Burdenen_US
dc.subjectNıtrıc-Oxıdeen_US
dc.subjectPharmacologıcal Changesen_US
dc.subjectInfluenza Infectıonen_US
dc.subjectBraın Developmenten_US
dc.subjectLıfe-Hıstoryen_US
dc.subjectIn-Uteroen_US
dc.subjectSchızophrenıaen_US
dc.titleMaternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspringen_US
dc.typeArticleen_US

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