Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester

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dc.authoridIrmak, M. Kemal/0000-0002-1903-8303
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082;
dc.authorwosidIrmak, M. Kemal/H-6667-2014
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidUz, Efkan/B-2943-2016
dc.contributor.authorKoltuksuz, U
dc.contributor.authorIrmak, MK
dc.contributor.authorKaraman, A
dc.contributor.authorUz, E
dc.contributor.authorVar, A
dc.contributor.authorÖzyurt, H
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:12:11Z
dc.date.available2024-08-04T20:12:11Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide (NO) plays an important role in modulating blood flow in normal and in several pathological conditions, and its levels seem to change with ischemia-reperfusion injuries. Caffeic acid phenethyl ester (CAPE), an active component of propolis, exhibits antioxidant properties. This experimental study was designed to determine the changes in NO levels and the effect of CAPE on NO levels after testicular torsion/ detorsion in rats. Thirty-five adult male albino rats were divided into four groups: sham operation (n = 8), torsion (n = 9), saline/detorsion (n = 9), and CAPE/detorsion (n = 9). Rats in the sham operation group were killed after the testes were handled without torsion. Rats in the torsion group were killed after 720 degrees clockwise testicular torsion for 2 h. CAPE was administered 30 min before detorsion in the CAPE/detorsion group and saline was administered in the saline/detorsion group. After 4 h of testicular detorsion in both of these groups, the rats were killed and bilateral orchiectomy was performed to determine the tissue levels of NO. The level of NO in the torsion group (113.77 +/- 33.18 nmol/g protein) was significantly higher than that of the sham operation group (64.53 +/- 29.64 nmol/g protein). In the saline/detorsion group, the NO level (31.26 +/- 12.58 nmol/g protein) was significantly lower than in the torsion and sham operation groups. CAPE administration in the CAPE/detorsion group seemed to raise the NO level (72.63 +/- 23.87 nmol/g protein) above the level of the sham operation group. Contralateral testes were not affected by the torsion/detorsion processes performed on the ipsilateral testes. These results show that NO levels increase with torsion and decrease with detorsion. CAPE administration seems to increase tissue NO levels and this may be important for protecting the testes from torsion/detorsion injuries.en_US
dc.identifier.doi10.1007/s002400000145
dc.identifier.endpage363en_US
dc.identifier.issn0300-5623
dc.identifier.issue6en_US
dc.identifier.pmid11221913en_US
dc.identifier.scopus2-s2.0-0034522399en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage360en_US
dc.identifier.urihttps://doi.org/10.1007/s002400000145
dc.identifier.urihttps://hdl.handle.net/11616/93271
dc.identifier.volume28en_US
dc.identifier.wosWOS:000166249700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttesticular torsionen_US
dc.subjectnitric oxideen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.titleTesticular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl esteren_US
dc.typeArticleen_US

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