Measurement of oxidant and antioxidant levels in liver tissue obtained from patients with liver transplantation: A case-control study

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidHargura, Abdirahman Sakulen/GQQ-8646-2022
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorAkbulut, Sami
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorSarici, Kemal Baris
dc.contributor.authorUremis, Nuray
dc.contributor.authorHargura, Abdirahman Sakulen
dc.contributor.authorKarakas, Serdar
dc.contributor.authorDogan, Ufuk Gunay
dc.date.accessioned2024-08-04T20:52:16Z
dc.date.available2024-08-04T20:52:16Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to compare oxidant and antioxidant substance accumulation in the liver tissues of patients with chronic liver disease (recipients) who underwent liver transplantation (LT) with living liver donors (LLDs) who underwent living donor hepatectomy (LDH).Methods: This prospective study included 160 recipients (LT group) and 40 LLDs (LLD group). During surgery, a piece of liver tissue measuring a minimum of 10 x 10 mm was obtained from the edge of the right lobe of the liver of recipients and LLDs, incubated for 10 min in saline to remove blood, and stored at -70 degrees C until biochemical analysis was performed. Catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), myeloperoxidase (MPO), prolidase, reduced glutathione (GSH), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), total thiol, native thiol, and disulfide levels were measured in stored liver tissues.Results: There was a statistically significant difference between LT and LLD groups in terms of age (p < 0.001), body mass index (p = 0.019), GSH-Px (p < 0.001), SOD (p = 0.001), MPO (p < 0.001), prolidase (p < 0.001), GSH (p < 0.001), and MDA (p = 0.003) values in favor of the LT group. Furthermore, there was a statistically significant difference between LT and LLD groups in terms of CAT (p < 0.001), TAS (p < 0.001), TOS (p < 0.001), OSI (p < 0.001), total thiol (p < 0.001), native thiol (p < 0.001), and disulfide (p < 0.001) values in favor of the LLD group. There were no differences between the groups in terms of sex.Conclusion: This study demonstrated that it is possible to assess the extent of oxidative stress in liver tissues by measuring the levels of antioxidant enzymes, oxidants, or the end-products of oxidative stress. With the use of optimum and minimally invasive methods, quantifying these molecules will potentially help evaluate the extent of liver disease and prognostication of liver cirrhosis.en_US
dc.identifier.doi10.1016/j.trim.2022.101697
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmid35985614en_US
dc.identifier.scopus2-s2.0-85136550474en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.trim.2022.101697
dc.identifier.urihttps://hdl.handle.net/11616/100856
dc.identifier.volume75en_US
dc.identifier.wosWOS:000859330200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTransplant Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver cirrhosisen_US
dc.subjectLiver recipientsen_US
dc.subjectLiving liver donorsen_US
dc.subjectOxidant and anti -oxidant balanceen_US
dc.subjectoxidativeen_US
dc.subjectstressen_US
dc.titleMeasurement of oxidant and antioxidant levels in liver tissue obtained from patients with liver transplantation: A case-control studyen_US
dc.typeArticleen_US

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