The Protective Effect of Chrysin Against Cisplatin Induced Ototoxicity in Rats

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dc.authoridTAN, MEHMET/0000-0001-8557-0886
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidTAN, MEHMET/ABI-7574-2020
dc.contributor.authorKelles, Mehmet
dc.contributor.authorTan, Mehmet
dc.contributor.authorKalcioglu, M. Tayyar
dc.contributor.authorToplu, Yuksel
dc.contributor.authorBulam, Nazire
dc.date.accessioned2024-08-04T20:39:59Z
dc.date.available2024-08-04T20:39:59Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOtotoxicity is a common side effect of cisplatin chemotherapy. The aim of this study was to investigate the potential protective effect of chrysin against cisplatin-induced ototoxicity. Thirty-four adult female Wistar albino rats were separated into four groups: a cisplatin group (Group A), with cisplatin administered to ten rats once daily for three consecutive days at doses of 8 mg/kg body weight intraperitoneally (i.p.); a cisplatin plus chrysin group (Group B), with 8 mg/kg of cisplatin administered i.p. daily to ten rats for three consecutive days and 25 mg/kg of chrysin administered via oral gavage in a corn oil for 5 days: a chrysin group (Group C), with 25 mg/kg of chrysin administered via oral gavage in corn oil for 5 days to seven rats; and a control group (Group D), with 5 ml/kg of corn oil administered to seven rats via oral gavage for 5 days. Distortion product otoacoustic emission measurements were performed in the same ear of the rats under general anesthesia at baseline and on the first and fifth days after drug administration. No significant differences were noted between the measurements either in the chrysin group or in the control group. In the cisplatin group, there was a significant worsening of hearing compared to baseline and the measurements on the fifth day at all frequencies. In the statistical analysis, a statistically significant difference was observed at 5039, 6351, 8003, and 10078 Hz frequencies between the measurements on the first and fifth days. In the cisplatin plus chrysin group, there were statistically significant differences at frequencies of 2,003 and 5,039 Hz between the measurements at baseline and on the fifth day, at 3,175 and 5,039 Hz between the measurements on the first and fifth days, and at 8,003 and 100,078 Hz between the measurements at baseline and on the first day. According to these results, this study demonstrates that cisplatin-related ototoxicity can be prevented in rats by the administration of chrysin.en_US
dc.identifier.doi10.1007/s12070-013-0695-x
dc.identifier.endpage374en_US
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issue4en_US
dc.identifier.pmid26396946en_US
dc.identifier.scopus2-s2.0-84919876302en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.1007/s12070-013-0695-x
dc.identifier.urihttps://hdl.handle.net/11616/96642
dc.identifier.volume66en_US
dc.identifier.wosWOS:000422259300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectChrysinen_US
dc.subjectOtoacoustic emissionsen_US
dc.titleThe Protective Effect of Chrysin Against Cisplatin Induced Ototoxicity in Ratsen_US
dc.typeArticleen_US

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