Autogenous Tooth Bone Graft and Simvastatin Combination Effect on Bone Healing

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dc.authoridKeleş, Ali/0000-0003-2835-767X
dc.authoridKIRTAY, Mustafa/0000-0003-2568-7470;
dc.authorwosidKeleş, Ali/J-5897-2015
dc.authorwosidKIRTAY, Mustafa/ABA-7066-2021
dc.authorwosidDodurga, Yavuz/C-5054-2014
dc.contributor.authorTasdemir, Ufuk
dc.contributor.authorKirtay, Mustafa
dc.contributor.authorKeles, Ali
dc.contributor.authorCil, Nazli
dc.contributor.authorAbban, Gulcin
dc.contributor.authorDodurga, Yavuz
dc.date.accessioned2024-08-04T20:49:04Z
dc.date.available2024-08-04T20:49:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Autogenous tooth bone grafts (ATGM) are materials prepared from extracted teeth and have been used for bone augmentation. These graft materials are known to have similar structures and components to bone grafts. In this sense, this study aimed to evaluate all the tooth layers mixed with simvastatin without any demineralization process effect on bone formation. Methods: In 60 Wistar albino rats, a standardized 6.0 m-diameter critical size bone defect was created in their calvarium. The study consists of 1 control and 4 experimental groups. In the control group (12 rats), the defects were left empty. The defects were grafted only with ATGM in Group 1, with ATGM mixed with simvastatin in Group 2, autogenous bone graft mixed with simvastatin in Group 3, and with xenogenic bone graft mixed with simvastatin in Group 4. The animals were sacrificed at the 7th and 28th days after operation. Results: PCR, micro CT and histological results show that bone formation was enhanced in the experimental groups in comparison to the control group. Group 1 and Group 2 had similar bone formation rate when compared to Group 3 and Group 4 at the 28th day after operation. Conclusion: This study concludes that mineralized teeth may be used for defect reconstruction without any demineralization process. Autogenous mineralized tooth bone graft should be mixed with simvastatin for bone regeneration like other grafts.en_US
dc.identifier.doi10.1097/SCS.0000000000006707
dc.identifier.endpage2354en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8en_US
dc.identifier.pmid32649532en_US
dc.identifier.scopus2-s2.0-85095385067en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2350en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000006707
dc.identifier.urihttps://hdl.handle.net/11616/99613
dc.identifier.volume31en_US
dc.identifier.wosWOS:000588153500067en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBMP-2en_US
dc.subjectsimvastatinen_US
dc.subjecttooth bone graften_US
dc.titleAutogenous Tooth Bone Graft and Simvastatin Combination Effect on Bone Healingen_US
dc.typeArticleen_US

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