The protective effects of thymoquinone against tartrazine-induced pancreatic injury and its impact on oxidative stress, caspase 3, blood glucose, insulin and cholesterol levels

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dc.contributor.authorErdemli, Zeynep
dc.contributor.authorZayman, Emrah
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorGul, Mehmet
dc.contributor.authorDemircigil, Nursena
dc.contributor.authorLevent, Ayse Betul
dc.contributor.authorAylaz, Bulent
dc.date.accessioned2026-04-04T13:33:33Z
dc.date.available2026-04-04T13:33:33Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractThe present study examined the effects of Tartrazine, a common industrial food colourant, on the pancreas and the protective role of Thymoquinone. Thirty-two Wistar albino male rats were randomly divided into four equal groups: Control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone. The rats received Tartrazine and Thymoquinone treatments for 21 days. At the end of this period, pancreatic tissues and blood samples were collected for analysis. Tartrazine administration elevated malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels, while decreasing glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) in pancreatic tissue. It increased glucose, total cholesterol, triglycerides, and LDL levels, while decreasing insulin and HDL levels in blood samples. Tartrazine administration aggravated pancreatic histopathology and enhanced Caspase-3 positive immunoreactivity. Thymoquinone administration reduced the harmful effects of Tartrazine on biochemical and histopathological parameters. Tartrazine administration negatively impacted pancreatic tissue and blood samples. The increased oxidant capacity and oxidative stress led to these harmful effects. Conversely, Thymoquinone alleviated oxidative stress by increasing antioxidant capacity and could act as a protective agent.
dc.identifier.doi10.1080/13813455.2025.2531121
dc.identifier.endpage11
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue1
dc.identifier.pmid40638124
dc.identifier.scopus2-s2.0-105010463269
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1080/13813455.2025.2531121
dc.identifier.urihttps://hdl.handle.net/11616/109236
dc.identifier.volume132
dc.identifier.wosWOS:001526084000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectTartrazine
dc.subjectthymoquinone
dc.subjectpancreas
dc.subjectoxidative stress
dc.subjectrats
dc.titleThe protective effects of thymoquinone against tartrazine-induced pancreatic injury and its impact on oxidative stress, caspase 3, blood glucose, insulin and cholesterol levels
dc.typeArticle

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