Effects of taurine and apocynin on the zone of stasis

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dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.contributor.authorOcuk, Ozcan
dc.contributor.authorFirat, Cemal
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorUlu, Ahmet
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:51:40Z
dc.date.available2024-08-04T20:51:40Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Among the zones of coagulation, hyperemia and stasis that occur in the burned area, the most intense metabolic process and the highest sensitivity to recovery with treatment is the zone of stasis.This metabolic process is related to how well the tissues in the zone of stasis can cope with oxidative stress. If the tissues in the zone of stasis are saved, the burn area will potentially heal faster and with less scar. In this study, we examined the effects of taurine amino acids and apocynin molecules on saving the tissues in the burn zone of stasis. Methods: The study was conducted with 48 rats. The burn zone of stasis was created according to the pattern previously described in the literature as comb burn model. In the 21-day study, biopsies were taken for histological examination on the 3rd, 7th and 21st days of the study. In addition, macroscopic photographic analysis was performed. Biopsies were taken for biochemical analysis on the 21st day. Histologically, inflammation, reepithelialization, and collagenization were evaluated, and the CD34 immunoreactivity was analysed. Biochemically, CAT, SOD, tGSH, TAS, TOS, MDA and PPC values were determined. Results: In the histological examination, on the 3rd, 7th and 21st days, inflammation was found to be reduced in the groups given taurine and apocynin on the 3rd day. On the 7th day, better reepithelialization and collagenization were observed in the group given taurine. Significant reepithelialization, collagenization and hair follicle development were observed in the groups given taurine and apocynin on the 21st day. In the biochemical analysis, the effects of apocynin on antioxidant enzymes were determined to be prominent. While we found no significant difference on the 3rd and 7th days in the photographic analysis, taurine and apocynin were observed to act synergistically on the 21st day and significantly reduced the burned areas. Conclusion: On the 3rd day, taurine and apocynin prevented inflammation, the effects of taurine in the zone of stasis in the early period (7th day) are more pronounced, the effect of apocynin on antioxidant enzymes is more pronounced. In the late period (21st day), taurine and apocynin were found to be more effective in saving the zone of stasis by creating a synergistic effect. (c) 2022 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.description.sponsorshipInonu University Scientific Research and Coordination Unit [TTU-2020-2180]en_US
dc.description.sponsorshipThis work was supported by Inonu University Scientific Research and Coordination Unit. The project number is registered as TTU-2020-2180.en_US
dc.identifier.doi10.1016/j.burns.2022.01.005
dc.identifier.endpage1862en_US
dc.identifier.issn0305-4179
dc.identifier.issn1879-1409
dc.identifier.issue8en_US
dc.identifier.pmid35153109en_US
dc.identifier.scopus2-s2.0-85124466701en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1850en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2022.01.005
dc.identifier.urihttps://hdl.handle.net/11616/100476
dc.identifier.volume48en_US
dc.identifier.wosWOS:000899578900009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjectBurnen_US
dc.subjectBurn healingen_US
dc.subjectTaurineen_US
dc.subjectZone of stasisen_US
dc.titleEffects of taurine and apocynin on the zone of stasisen_US
dc.typeArticleen_US

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