Resveratrol ameliorates cisplatin-induced oxidative injury in New Zealand rabbits

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridAkgoz, Muslum/0000-0001-5065-8087
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidAkgoz, Muslum/AAG-4598-2019
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorAkgoz, Muslum
dc.contributor.authorOzen, Hasan
dc.contributor.authorKaraman, Musa
dc.contributor.authorKart, Asim
dc.contributor.authorGecer, Murat
dc.contributor.authorAtalan, Gultekin
dc.date.accessioned2024-08-04T20:40:23Z
dc.date.available2024-08-04T20:40:23Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigated the preventive role of resveratrol in cisplatin-induced nephrotoxicity. The study used groups of New Zealand rabbits that were treated as follows: group C (cisplatin treated), group R (resveratrol treated), group R+C (resveratrol + cisplatin treatment), and group E (control group). Kidney levels of glutathione were significantly lower in group C than in groups E and R, whereas glutathione levels in group R+C were found to be similar to the control values. Malondialdehyde levels in group C were significantly higher than in groups E and R. However, malondialdehyde levels in group R+C were similar to group E. Kidney levels of nitric oxide were significantly higher in the cisplatin group than in the control, whereas nitric oxide levels were at basal values in group R+C. Cisplatin treatment significantly reduced kidney levels of glutathione peroxidase, superoxide dismutase, and catalase activity compared with those of group E, whereas resveratrol treatment significantly increased levels of glutathione peroxidase, superoxide dismutase, and catalase activity in group R+C. However, cisplatin injection did not affect mRNA levels of glutathione peroxidase, superoxide dismutase, or catalase enzymes. Histopathological and immunohistochemical analyses indicated that cisplatin caused kidney damage, which was mostly prevented by resveratrol treatment. In conclusion, resveratrol ameliorates cisplatin-induced oxidative injury in the kidney of rabbit.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-104V122]en_US
dc.description.sponsorshipThis work was supported by a grant from The Scientific and Technological Research Council of Turkey (TUBITAK-104V122).en_US
dc.identifier.doi10.1139/cjpp-2014-0420
dc.identifier.endpage735en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue8en_US
dc.identifier.pmid26243022en_US
dc.identifier.scopus2-s2.0-84938567733en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage727en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2014-0420
dc.identifier.urihttps://hdl.handle.net/11616/96888
dc.identifier.volume93en_US
dc.identifier.wosWOS:000359163800015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectresveratrolen_US
dc.subjectcisplatinen_US
dc.subjectantioxidant enzymesen_US
dc.subjectnephrotoxicityen_US
dc.subjectrabbiten_US
dc.titleResveratrol ameliorates cisplatin-induced oxidative injury in New Zealand rabbitsen_US
dc.typeArticleen_US

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