Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities

Basit Öğe Kaydı
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidTouj, Nedra/G-6828-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidTouj, Nedra/AAM-2982-2021
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorTouj, Nedra
dc.contributor.authorAl-Ayed, Abdullah S.
dc.contributor.authorSauthier, Mathieu
dc.contributor.authorMansour, Lamjed
dc.contributor.authorHarrath, Abdel Halim
dc.contributor.authorAl-Tamimi, Jamil
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:45:35Z
dc.date.available2024-08-04T20:45:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN,N-Substituted benzimidazole salts were successfully synthesized and characterized by H-1-NMR, C-13 {H-1} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 degrees C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a-i and 4a-i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 g mL(-1) against MDA-MB-231 and 4.85 g mL(-1) against MCF7 respectively.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this research group (No. RG-1435-023).en_US
dc.identifier.doi10.1039/c8ra08897g
dc.identifier.endpage40015en_US
dc.identifier.issn2046-2069
dc.identifier.issue70en_US
dc.identifier.pmid35558245en_US
dc.identifier.scopus2-s2.0-85058245846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage40000en_US
dc.identifier.urihttps://doi.org/10.1039/c8ra08897g
dc.identifier.urihttps://hdl.handle.net/11616/98570
dc.identifier.volume8en_US
dc.identifier.wosWOS:000452778800026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFriedel-Crafts Acylationen_US
dc.subjectComplexes Synthesisen_US
dc.subjectPyridine Halidesen_US
dc.subjectConvenient Accessen_US
dc.subjectGrignard-Reagentsen_US
dc.subjectMetal-Complexesen_US
dc.subjectAryl Halidesen_US
dc.subjectLigandsen_US
dc.subjectDerivativesen_US
dc.subjectChloridesen_US
dc.titleEfficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu