A preliminary study of fumaric acid, called allomaleic acid, as a pharmaceutical antimicrobial compound

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dc.contributor.authorUnver, Tuba
dc.date.accessioned2026-04-04T13:14:36Z
dc.date.available2026-04-04T13:14:36Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractThe emergence of antimicrobial resistance in microorganisms and the adverse effects associated with antibiotic use have necessitated the exploration of new, natural substances for antimicrobial treatments. Fumaric acid, or allomaleic acid, is a natural bioactive compound primarily derived from plant-based products. Fumaric acid has potential analgesic, anti-inflammatory, antioxidant, anti-psoriatic, chemopreventive, immunomodulatory, and neuroprotective properties. So far, studies on the antimicrobial activity of fumaric acid have used a plant ingredient. The antimicrobial activity was attributed to fumaric acid because it was detected in large amounts in herbal products. In this preliminary study, the antibacterial and antifungal properties of pure fumaric acid (99+%) were determined by the microdilution method. As a result of the antimicrobial study, the Minimum Inhibitory Concentration (MIC) values of fumaric acid against Candida tropicalis, Candida krusei, Candida albicans, Candida glabrata, and Candida parapsilosis were 9.375, 37.5, 4.687, 4.687, and 1.172 mg/mL, respectively. Moreover, bacterial cells were found to be approximately one hundred times more sensitive to fumaric acid than Candida cells. The MIC values of fumaric acid against Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes were determined as 150 µg /mL, and against Staphylococcus aureus was 75 µg /mL. These results showed that pure fumaric acid has a potent inhibitory effect against pathogenic or opportunistic microorganisms. Its unique properties and potential as an antimicrobial agent make it a compelling study area. Therefore, the usability of fumaric acid in the pharmacotherapeutic field is promising for future advanced in vivo studies.
dc.identifier.doi10.5455/medscience.2024.04.031
dc.identifier.endpage387
dc.identifier.issn2147-0634
dc.identifier.issue2
dc.identifier.startpage383
dc.identifier.trdizinid1271540
dc.identifier.urihttps://doi.org/10.5455/medscience.2024.04.031
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1271540
dc.identifier.urihttps://hdl.handle.net/11616/107322
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorUnver, Tuba
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectMikrobiyoloji
dc.subjectToksikoloji
dc.titleA preliminary study of fumaric acid, called allomaleic acid, as a pharmaceutical antimicrobial compound
dc.typeArticle

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