Mean platelet volume as an inexpensive bio-marker of endometriosis

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dc.authoridBodur, Serkan/0000-0003-4461-9174
dc.authoridBabayigit, Mustafa/0000-0001-5313-9186
dc.authorwosidBodur, Serkan/A-7362-2012
dc.authorwosidköleli, ışıl/ABI-7318-2020
dc.authorwosidDural, Ozlem/AAY-2248-2020
dc.contributor.authorBakir, Vuslat Lale
dc.contributor.authorDundar, Ozgur
dc.contributor.authorBodur, Serkan
dc.contributor.authorGoksedef, Behiye Pinar
dc.contributor.authorAksoy, Huseyin
dc.contributor.authorAlanbay, Ibrahim
dc.contributor.authorKoleli, Isil
dc.date.accessioned2024-08-04T20:41:51Z
dc.date.available2024-08-04T20:41:51Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Increased platelet activation has also been suggested to play a pivotal role in the development and progression of inflammation. Recently, mean platelet volume (MPV) has been investigated as a simple inflammatory marker in several diseases and it was found that MPV can be used as a marker of inflammatory disease. Therefore this study was designed to investigate and compare the values of MPV in patients with endometriosis and the MPV values in healthy women. Materials and methods: Patients with endometriosis (n = 297) and symptom-free, healthy, age-matched controls underwent tubal ligation (n = 36) were retrospectively evaluated and recruited to the study at three tertiary centers between January 2008 and December 2014. For further analysis, patients with endometriosis were divided into initial endometriosis (n = 129) and advanced endometriosis (n = 168) groups according to the severity of the disease. Receiver Operating Characteristic (ROC) curve and sensitivity and specificity report were performed for MPV value to evaluate differences between the groups. Results: MPV in patients with endometriosis were found to be higher than the control group (8.80 +/- 1.08 fL vs 8.11 +/- 1.03 fL, respectively; P < 0.001). There was no significant difference regarding mean MPV between the patients with advanced and initial endometriosis (8.72 +/- 1.60 fL and 8.90 +/- 0.97 fL, respectively; P = 0.15). ROC curve analysis suggested that the optimum MPV cut-off value for endometriosis was 8.55 fL, with a sensitivity, specificity, of 61% and 61%, respectively (AUC: 0.671). Conclusion: This study showed that significantly higher MPV levels were found in the patients with endometriosis and confirmed the previous studies indicating that endometriosis is an inflammatory process. MPV is an important, simple, inexpensive, and effortless hematological parameter and can be useful in evaluation of endometriosis patients.en_US
dc.identifier.endpage9436en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84977080523en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9431en_US
dc.identifier.urihttps://hdl.handle.net/11616/97392
dc.identifier.volume9en_US
dc.identifier.wosWOS:000379156000068en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriosisen_US
dc.subjectinflammationen_US
dc.subjectmean platelet volumeen_US
dc.titleMean platelet volume as an inexpensive bio-marker of endometriosisen_US
dc.typeArticleen_US

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