Protective Effect of ?-Carotene on Methotrexate-Induced Oxidative Liver Damage

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidERDOĞAN, Ali/ABG-8548-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorCetin, Asli
dc.contributor.authorErdogan, Ali
dc.contributor.authorOzturk, I. Cetin
dc.date.accessioned2024-08-04T20:32:25Z
dc.date.available2024-08-04T20:32:25Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the authors aimed to investigate the role of oxidative stress on the hepatic damage caused by methotrexate (MTX) and the possible protective effects of beta-carotene against this damage. The rats were divided into four groups as control, MTX (20 mg/kg ip), beta-carotene (10 mg/kg/day ip) | MTX, and beta-carotene. Histopathologic alterations were evaluated for defining the liver damage. The tissue, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GP-x) contents and serum aspartate aminotransferase (AST) and alanine aminotranferase (ALT) activities were also examined. Histopathologic damage for each group score findings have been determined as control: 0.66 +/- 0.33; MTX: 7.0 +/- 0.68; beta-carotene | MTX: 3.3 +/- 0.42; and beta-carotene: 0.5 +/- 0.3. In the MTX-treated group, MDA, AST, and ALT values were increased, while SOD and GP-x values were decreased compared with the control group. In the beta-carotene + MTX-treated group, AST and ALT values significantly decreased, while all other parameters were similar to the control group. This study shows that beta-carotene has a protective effect on MTX-induced oxidative hepatic damage. Consequently, it seems that an antioxidant agents like beta-carotene may be useful in decreasing the side effects of chemotherapy.en_US
dc.identifier.doi10.1177/0192623310367806
dc.identifier.endpage597en_US
dc.identifier.issn0192-6233
dc.identifier.issn1533-1601
dc.identifier.issue4en_US
dc.identifier.pmid20448084en_US
dc.identifier.scopus2-s2.0-77953672605en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage592en_US
dc.identifier.urihttps://doi.org/10.1177/0192623310367806
dc.identifier.urihttps://hdl.handle.net/11616/95064
dc.identifier.volume38en_US
dc.identifier.wosWOS:000278809600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicologic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidantsen_US
dc.subjectbeta-caroteneen_US
dc.subjectmethotrexateen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.titleProtective Effect of ?-Carotene on Methotrexate-Induced Oxidative Liver Damageen_US
dc.typeArticleen_US

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