Histopathologic and electron microscopic investigation of the damage to liver tissue caused by parenteral nutrition combined with starvation in rabbits

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorGul, Mehmet
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:50:36Z
dc.date.available2024-08-04T20:50:36Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim of the study: To conduct a histopathological examination of the damaging effects of the combination of parenteral nutrition (PN) with starvation on liver tissue using transmission electron and light microscopy. Material and methods: Four groups (n = 14 each) consisting of equal numbers of female and male New Zealand rabbits were formed: a group left completely unfed and receiving full-dose PN (full-dose PN group), a group provided with feed covering half its nutritional needs and receiving half-dose PN (half-dose PN + oral nutrition group), a group provided with feed covering half its nutritional needs (semi-starvation group), and a group provided with feed covering all its nutritional needs (control group). After 10 days, all rabbits were weighed, anesthetized, and euthanized, and liver tissue samples were collected. Histopathologic examination was performed by a surgical pathologist blinded to the experimental groups. Portal inflammation, ballooning degeneration, apoptosis and fibrosis were evaluated and statistically analyzed. Results: Severe portal inflammation, moderate portal fibrosis, slight ballooning degeneration, and moderate apoptosis were found in the full-dose PN group. Mild portal inflammation, fibrosis and mild apoptosis were found in the half-dose PN + oral nutrition group. The results of the other two groups were found normal. Conclusions: Liver damage caused by PN combined with starvation can be devastating. The damage can be minimized by combining PN with enteral nutrition.en_US
dc.identifier.doi10.5114/ceh.2021.106227
dc.identifier.endpage222en_US
dc.identifier.issn2392-1099
dc.identifier.issn2449-8238
dc.identifier.issue2en_US
dc.identifier.pmid34295990en_US
dc.identifier.scopus2-s2.0-85113741477en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.5114/ceh.2021.106227
dc.identifier.urihttps://hdl.handle.net/11616/100168
dc.identifier.volume7en_US
dc.identifier.wosWOS:000672794700013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofClinical and Experimental Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver damageen_US
dc.subjectparenteral nutritionen_US
dc.subjecthistopathologyen_US
dc.titleHistopathologic and electron microscopic investigation of the damage to liver tissue caused by parenteral nutrition combined with starvation in rabbitsen_US
dc.typeArticleen_US

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