The Role of Aurora Kinase A in HBV-Associated Hepatocellular Carcinomas: A Molecular and Immunohistochemical Study

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dc.contributor.authorHuz, Mustafa
dc.contributor.authorKaradag Soylu, Nese
dc.contributor.authorKoc, Ahmet
dc.contributor.authorKucukakcali, Zeynep
dc.contributor.authorDanis, Nefsun
dc.contributor.authorOzhan, Onural
dc.date.accessioned2026-04-04T13:31:09Z
dc.date.available2026-04-04T13:31:09Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives: Although Aurora kinase A (AURKA) expression has been investigated in many cancer types, studies focusing on its role in hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) are limited. In this study, we examined the activity of AURKA and its substrates (PLK1, P53, and BRCA1) in HBV-HCC and cryptogenic hepatocellular carcinoma (Cr-HCC) cases. Methods: The study groups consisted of HBV-HCC, Cr-HCC, and healthy liver tissue cases. AURKA copy number variation (CNV) was analyzed using molecular methods. AURKA expression was evaluated by molecular and immunohistochemical (IHC) methods. AURKA substrates P53(Ser315), PLK1(Thr210), and BRCA1 were also analyzed by IHC. Results: There was no increase in AURKA gene copy number among the groups (2-triangle triangle Ct < 2). AURKA level was significantly increased in both test groups (p < 0.001). At the protein level, AURKA was significantly higher in both cancer groups compared to the control group (p < 0.001). Phospho-P53(Ser315) levels were significantly higher in both HBV-HCC and Cr-HCC groups compared to the control group (p = 0.002 and p < 0.001, respectively). Cr-HCC cases also showed significantly higher levels compared to HBV-HCC (p = 0.025). For phospho-PLK1(Thr210), Cr-HCC cases showed statistically higher expression compared to both the control group and HBV-HCC cases (p = 0.001).
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2021/2713]
dc.description.sponsorshipThis research was supported by Inonu University Scientific Research Projects Unit with project number 2021/2713.
dc.identifier.doi10.3390/diagnostics16010160
dc.identifier.issn2075-4418
dc.identifier.issue1
dc.identifier.orcid0000-0003-3484-2137
dc.identifier.pmid41515655
dc.identifier.scopus2-s2.0-105027860627
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/diagnostics16010160
dc.identifier.urihttps://hdl.handle.net/11616/108602
dc.identifier.volume16
dc.identifier.wosWOS:001658679500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectHBV-related HCC
dc.subjectcryptogenic HCC
dc.subjectAurora kinase A
dc.subjectphospho-PLK1
dc.subjectphospho-P53
dc.subjectBRCA1
dc.titleThe Role of Aurora Kinase A in HBV-Associated Hepatocellular Carcinomas: A Molecular and Immunohistochemical Study
dc.typeArticle

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