The effects of irradiation on the blood dynamics

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dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorErkal, Haldun Suekrue
dc.contributor.authorKarakoc, Yunus
dc.contributor.authorSerin, Meltem
dc.date.accessioned2024-08-04T20:31:14Z
dc.date.available2024-08-04T20:31:14Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The present study evaluates the effects of irradiation on the blood dynamics. Materials and methods: Thirty-six volunteers providing written consent participated. A blood sample was transferred into three tubes containing CPDA-1 solution while another blood sample was transferred into three tubes containing heparin. Each tube containing CPDA-1 solution was paired with another tube containing heparin. The first pair was not irradiated, not stored and analyzed immediately (Group 1). The second pair was not irradiated, stored and analyzed at seven days (Group 2). The third pair was irradiated, stored and analyzed at seven days (Group 3). The blood count was performed and the blood viscosity was determined. Results: The mean hemoglobin contents were 126 g/l for Group 1, 128 g/l for Group 2 and 129 g/l for Group 3. For the mean hemoglobin contents, the difference between Group 1 and Group 3 (P < 0.001) and Group 2 and Group 3 (P = 0.01) were significant. The mean red blood cell volumes were 81.8 fl for Group 1, 82.1 fl for Group 2 and 82.3 fl for Group 3. For the mean red blood cell volumes, the difference between Group 1 and Group 2 (P = 0.003) and Group 1 and Group 3 (P = 0.006) were significant. The mean blood viscosities were 2.2 mPa s for Group 1, 2.8 mPa s for Group 2 and 3.2 mPa s for Group 3. For the mean blood viscosities, the difference between Group 1 and Group 2 (P < 0.001), Group 1 and Group 3 (P < 0.001) and Group 2 and Group 3 (P = 0.004) were significant. Conclusion: The present study indicates that the recommended doses of irradiation for the blood products to be used in attempt to prevent the transfusion associated graft versus host disease leads to marked alterations in the blood dynamics and might decrease the viability of the red blood cells following transfusion.en_US
dc.identifier.doi10.3233/CH-2009-1177
dc.identifier.endpage267en_US
dc.identifier.issn1386-0291
dc.identifier.issue4en_US
dc.identifier.pmid19318719en_US
dc.identifier.scopus2-s2.0-65549167392en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage263en_US
dc.identifier.urihttps://doi.org/10.3233/CH-2009-1177
dc.identifier.urihttps://hdl.handle.net/11616/94799
dc.identifier.volume41en_US
dc.identifier.wosWOS:000264746500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofClinical Hemorheology and Microcirculationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTransfusion associated graft versus host diseaseen_US
dc.subjectirradiationen_US
dc.subjectblood dynamicsen_US
dc.titleThe effects of irradiation on the blood dynamicsen_US
dc.typeArticleen_US

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