Prognostic Significance of Laboratory Parameters for Survival of Recipients after Living Donor Liver Transplantation
Küçük Resim Yok
Tarih
2026
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Egyptian Society Surgeons
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The routine laboratory factors affecting the 1-year survival of recipients after transplantation, and the predictive value of the parameters were investigated in this study. Materials and Methods: For this purpose, early post-operative laboratory parameters were recorded in 93 living donor liver transplant recipients, and were analyzed for their association with mortality during 1 year period. Univariate and multivariate logistic regression analyses and logistic Forward Wald and Logistic Backward Wald regression analysis were performed for predicting the survival of the recipients. Results: The calculated AUC value for the mortality in recipients was 0.762, (95% CI 0.607-0.917) (P= 0.005) for neutrophil-lymphocyte ratio, and the AUC value for albumin was 0.711, (95% CI 0.573-0.848) (P= 0.025). These dates were considered strong predictive factors and were higher than other liver functional tests. A cut-off value of total bilirubin >8.76mg/dL, was superior to standard liver tests, showing a sensitivity of 72.4 +/- 13.4% and a specificity of 84.1 +/- 4.4% for predicting 1-year lethal outcomes (P<0.001), ammonia cutoff level >190ug/dl showed 63.6 +/- 14.5% sensitivity and 87.0 +/- 4.1% specificity, the neutrophil-lymphocyte ratio achieved a sensitivity of 54.5 +/- 15.0% and a specificity of 88.4 +/- 3.9% with a cut-off value of 6.5. Conclusions: The overall diagnostic values of total bilirubin, ammonia, and neutrophil-lymphocyte ratio for predicting a 1-year lethal outcome were higher than other parameters, being 81.5%, 82.7%, and 82.7%, respectively. The combined prognostic sensitivity of albumin, total bilirubin, and neutrophil-lymphocyte ratio for 1-year survival was 91.3% (P>0.001). These findings may be potentially translatable for clinical use.
Açıklama
Anahtar Kelimeler
Gaft survival, liver transplantation, prognostic accuracy
Kaynak
Egyptian Journal of Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
45
Sayı
1
