Prognostic Significance of Laboratory Parameters for Survival of Recipients after Living Donor Liver Transplantation

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dc.contributor.authorNovruzov, Namig
dc.contributor.authorErsan, Veysel
dc.contributor.authorBayramov, Nuru
dc.contributor.authorAliyev, Eldar
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:32:56Z
dc.date.available2026-04-04T13:32:56Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: The routine laboratory factors affecting the 1-year survival of recipients after transplantation, and the predictive value of the parameters were investigated in this study. Materials and Methods: For this purpose, early post-operative laboratory parameters were recorded in 93 living donor liver transplant recipients, and were analyzed for their association with mortality during 1 year period. Univariate and multivariate logistic regression analyses and logistic Forward Wald and Logistic Backward Wald regression analysis were performed for predicting the survival of the recipients. Results: The calculated AUC value for the mortality in recipients was 0.762, (95% CI 0.607-0.917) (P= 0.005) for neutrophil-lymphocyte ratio, and the AUC value for albumin was 0.711, (95% CI 0.573-0.848) (P= 0.025). These dates were considered strong predictive factors and were higher than other liver functional tests. A cut-off value of total bilirubin >8.76mg/dL, was superior to standard liver tests, showing a sensitivity of 72.4 +/- 13.4% and a specificity of 84.1 +/- 4.4% for predicting 1-year lethal outcomes (P<0.001), ammonia cutoff level >190ug/dl showed 63.6 +/- 14.5% sensitivity and 87.0 +/- 4.1% specificity, the neutrophil-lymphocyte ratio achieved a sensitivity of 54.5 +/- 15.0% and a specificity of 88.4 +/- 3.9% with a cut-off value of 6.5. Conclusions: The overall diagnostic values of total bilirubin, ammonia, and neutrophil-lymphocyte ratio for predicting a 1-year lethal outcome were higher than other parameters, being 81.5%, 82.7%, and 82.7%, respectively. The combined prognostic sensitivity of albumin, total bilirubin, and neutrophil-lymphocyte ratio for 1-year survival was 91.3% (P>0.001). These findings may be potentially translatable for clinical use.
dc.identifier.doi10.21608/EJSUR.2025.409715.1577
dc.identifier.endpage219
dc.identifier.issn1110-1121
dc.identifier.issn1687-7624
dc.identifier.issue1
dc.identifier.startpage215
dc.identifier.urihttps://doi.org/10.21608/EJSUR.2025.409715.1577
dc.identifier.urihttps://hdl.handle.net/11616/108808
dc.identifier.volume45
dc.identifier.wosWOS:001708552500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherEgyptian Society Surgeons
dc.relation.ispartofEgyptian Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectGaft survival
dc.subjectliver transplantation
dc.subjectprognostic accuracy
dc.titlePrognostic Significance of Laboratory Parameters for Survival of Recipients after Living Donor Liver Transplantation
dc.typeArticle

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