Preparation of sulfatide mimicking oleic acid sulfated chitosan as a potential inhibitor for metastasis

Basit Öğe Kaydı
dc.authoridAkkaya, Birnur/0000-0001-9139-1884
dc.authorwosidkocabay, samet/AAA-6158-2021
dc.authorwosidkocabay, samet/HZI-2537-2023
dc.authorwosidAkkaya, Birnur/AAZ-2285-2021
dc.contributor.authorKocabay, Samet
dc.contributor.authorAkkaya, Birnur
dc.date.accessioned2024-08-04T20:46:58Z
dc.date.available2024-08-04T20:46:58Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSulfatide is associated with numerous health problems, affecting different parts of the human body, including the metastasis; however, the underlying mechanisms are yet to be fully elucidated. Sulfatide has been used to potential inhibitor for tumor cell metastasis. In the present study we synthesized oleic acid sulfated chitosan (OlcShCs). It shows structural similarity to sulfatide because of its functional groups (sulfate and fatty acyl chains). Chitosan has smart properties such as biocompatibility, biodegradability and non-toxicity. We have prepared oleic acid sulfated chitosan (OlcShCs) by chitosan modification to mimic sulfatide. Its structure was characterized by FT-IR, H-NMR, and thermogravimetric analysis. After characterization studies its antimicrobial, antifungal and cytotoxic properties were investigated. Oleic acid sulfated chitosan (OlcShCs) was tested for its anti-cancer potential against human cancer cell lines (HeLa (ATCC (R) CCL-2 (TM))) for 24 h, 48 h and 72 h using the MIT assays. This new material which is soluble at physiological conditions, is a potential candidate for further metastasis inhibition investigations. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research Project (CUBAP) [F-575]en_US
dc.description.sponsorshipThis study was supported by Cumhuriyet University Scientific Research Project (CUBAP) (Project number:F-575).en_US
dc.identifier.doi10.1016/j.ijbiomac.2019.10.119
dc.identifier.endpage798en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid31739035en_US
dc.identifier.scopus2-s2.0-85075883539en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage792en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.10.119
dc.identifier.urihttps://hdl.handle.net/11616/99085
dc.identifier.volume147en_US
dc.identifier.wosWOS:000525864700081en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectSulfatideen_US
dc.subjectAnti-microbialen_US
dc.subjectAnti-fungalen_US
dc.subjectCytotoxicen_US
dc.subjectMetastasisen_US
dc.titlePreparation of sulfatide mimicking oleic acid sulfated chitosan as a potential inhibitor for metastasisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu