Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia

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dc.authoridBüyükavcı, Raikan Soydemir/0000-0002-2234-7158
dc.authoridAkturk, SEMRA/0000-0001-9960-6851;
dc.authorwosidBüyükavcı, Raikan Soydemir/Q-5336-2018
dc.authorwosidAkturk, SEMRA/KTH-9105-2024
dc.authorwosidAKTÜRK, SEMRA/ABI-2757-2020
dc.contributor.authorAkturk, Semra
dc.contributor.authorBuyukavci, Raikan
dc.date.accessioned2024-08-04T20:43:06Z
dc.date.available2024-08-04T20:43:06Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (MPV) are the determinants of platelet activation and studied as markers in inflammatory diseases. The aim of the present study was to evaluate levels of NLR,PDW and MPV in patients with fibromyalgia. A total of 197 FMS patients and 53 healthy controls are included in the study. Demographic characteristics, erythrocyte sedimentation rate, C-reactive protein, neutrophil, lymphocyte and platelet counts, platelet distribution width and mean platelet volume levels were recorded. In the patient group, the blood NLR and MPV were significantly higher and the PDW was significantly lower compared to the control group. In the roc curve analysis, blood PDW >= had 90.4% sensitivity and 90% specificity in predicting fibromyalgia. The results of this study suggest NLR and PDW as promising inflammatory markers indicating fibromyalgia and may be beneficial in facilitating the diagnosis of FMS patients.en_US
dc.identifier.doi10.1007/s10067-017-3647-0
dc.identifier.endpage1889en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue8en_US
dc.identifier.pmid28466420en_US
dc.identifier.scopus2-s2.0-85018399625en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1885en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-017-3647-0
dc.identifier.urihttps://hdl.handle.net/11616/97792
dc.identifier.volume36en_US
dc.identifier.wosWOS:000406182900025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibromyalgiaen_US
dc.subjectInflammatory markersen_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.subjectPlatelet distribution widthen_US
dc.titleEvaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgiaen_US
dc.typeArticleen_US

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