Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behget Disease

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dc.authoridPekdemir, Hasan/0000-0002-4913-5120
dc.authoridTaşolar, Hakan/0000-0002-1249-7240
dc.authoridAltunisik, Nihal/0000-0001-6844-1097
dc.authoridDemiröz Tasolar, Sevgi/0000-0002-9836-6814;
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidBayramoğlu, Adil/ABF-2802-2020
dc.authorwosidTaşolar, Hakan/ABG-4466-2020
dc.authorwosidAltunisik, Nihal/ABG-8567-2020
dc.authorwosidDemiröz Tasolar, Sevgi/KTI-6349-2024
dc.authorwosidBayramoğlu, Adil/ABI-3122-2020
dc.authorwosidcetin, mustafa/AAZ-2093-2020
dc.contributor.authorTasolar, Hakan
dc.contributor.authorTasolar, Sevgi
dc.contributor.authorKurtulus, Duygu
dc.contributor.authorAltun, Burak
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorOmur, Yilmaz
dc.contributor.authorBalli, Mehmet
dc.date.accessioned2024-08-04T20:39:50Z
dc.date.available2024-08-04T20:39:50Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives-Owing to the fact that the potential frequency of endothelial dysfunction and early atherosclerosis might be higher in Behcet disease, characterized by acute and chronic inflammatory attacks, it may lead to impairment in flow-mediated dilatation and an increase in epicardial adipose tissue thickness. Therefore, we aimed to evaluate whether epicardial adipose tissue thickness and brachial artery flow-mediated dilatation as markers of early atherosclerosis and endothelial dysfunction were associated with Behcet disease. Methods-Thirty-five patients with Behcet disease and 35 healthy volunteers were included in this study. Epicardial adipose tissue was identified as an anechoic space between epicardial layers on 2-dimensional images, and its thickness was measured on the free wall of the right ventricle. Right brachial artery flow-mediated dilatation was assessed according to recent guidelines. Results-Serum gamma-glutamyl transferase (GGT) levels and epicardial adipose tissue thickness were significantly higher (P = .001; P < .001 respectively), whereas flow-mediated, endothelium-dependent dilatation was significantly lower in the Behcet disease group than controls. (P < .001). There was a significant negative association between epicardial adipose tissue thickness and flow-mediated dilatation (P < .001). Epicardial adipose tissue thickness was also positively correlated with Behcet disease activity (P < .001), Behcet disease duration (P < .001), and waist circumference (P < .001). Flow-mediated dilatation was negatively correlated with GGT (P < .001), Behcet disease activity (P < .001), and age (P < .001). There was also a significant association between GGT and Behcet disease activity (P < .001). Conclusions-We found that epicardial adipose tissue thickness was significantly higher and flow-mediated dilatation was significantly lower in patients with Behcet disease than in controls. We suggest that identification of increased epicardial adipose tissue might aid in the diagnosis and treatment of possible coronary artery disease in patients with Behcet disease.en_US
dc.identifier.doi10.7863/ultra.33.8.1393
dc.identifier.endpage1400en_US
dc.identifier.issn0278-4297
dc.identifier.issn1550-9613
dc.identifier.issue8en_US
dc.identifier.pmid25063404en_US
dc.identifier.scopus2-s2.0-84905730915en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1393en_US
dc.identifier.urihttps://doi.org/10.7863/ultra.33.8.1393
dc.identifier.urihttps://hdl.handle.net/11616/96535
dc.identifier.volume33en_US
dc.identifier.wosWOS:000339704200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Ultrasound in Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectBehcet diseaseen_US
dc.subjectbrachial artery flow-mediated dilatationen_US
dc.subjectepicardial adipose tissue thicknessen_US
dc.subjectgamma-glutamyl transferaseen_US
dc.subjectvascular ultrasounden_US
dc.titleIncreased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behget Diseaseen_US
dc.typeArticleen_US

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