Relationship between hypogammaglobulinemia and severity of atopic dermatitis

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dc.authoridtopal, erdem/0000-0002-4439-2689
dc.authorwosidCeliksoy, Mehmet Halil/A-3889-2015
dc.authorwosidtopal, erdem/ABI-7545-2020
dc.contributor.authorCeliksoy, Mehmet Halil
dc.contributor.authorTopal, Erdem
dc.contributor.authorSancak, Recep
dc.contributor.authorCatal, Ferhat
dc.contributor.authorSogut, Ayhan
dc.date.accessioned2024-08-04T20:39:54Z
dc.date.available2024-08-04T20:39:54Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Atopic dermatitis is an itchy, inflammatory, chronic, or chronically relapsing skin disease. The disease occurs in people who have an atopic tendency or may appear as a clinical sign of primary immunodeficiency. Objectives: To determine the relation between severity of atopic dermatitis and hypogammaglobulinemia. Methods: One hundred sixty pediatric patients with atopic dermatitis (98 boys and 62 girls, 1-60 months old, median age 14.5 months) and 95 healthy children (57 boys and 38 girls, median age 16 months; control group) were included in the study. In patients with atopic dermatitis, the severity of disease was determined by the SCORing Atopic Dermatitis index. Serum immunoglobulin levels of all patients and children in the control group were measured by nephelometry on admission. Results: The incidence of hypogammaglobulinemia was higher in patients with atopic dermatitis than in the control group (P = .009). The main reason for this difference was the low level of IgG in the atopic dermatitis group (P = .024). Analysis of the relation between hypogammaglobulinemia and the severity of atopic dermatitis showed no statistically significant difference between the group with mild to moderate atopic dermatitis and the group with severe atopic dermatitis with respect to hypogammaglobulinemia (P = .859), IgG (P = .068), IgA (P = .410), and IgM (P = .776) values. Conclusion: Hypogammaglobulinemia was more frequent in patients with atopic dermatitis compared with the control group, mostly owing to the low IgG level. Hypogammaglobulinemia is not associated with the severity of atopic dermatitis. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.anai.2014.06.025
dc.identifier.endpage469en_US
dc.identifier.issn1081-1206
dc.identifier.issn1534-4436
dc.identifier.issue4en_US
dc.identifier.pmid25037609en_US
dc.identifier.scopus2-s2.0-84908470210en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.1016/j.anai.2014.06.025
dc.identifier.urihttps://hdl.handle.net/11616/96586
dc.identifier.volume113en_US
dc.identifier.wosWOS:000343113400020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAnnals of Allergy Asthma & Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.titleRelationship between hypogammaglobulinemia and severity of atopic dermatitisen_US
dc.typeArticleen_US

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