The protective effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in rat ovary

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorCelik, O
dc.contributor.authorTurkoz, Y
dc.contributor.authorHascalik, S
dc.contributor.authorHascalik, M
dc.contributor.authorCigremis, Y
dc.contributor.authorMizrak, B
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This experimental study was designed to determine the changes in tissue levels of malondialdehyde, end-product of lipid peroxidation (MDA), reduced glutathione (GSH) and xanthine oxidase (XO) and the effect of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) on these metabolite levels after adnexal torsion-detorsion model in rats. Method: Forty adult female albino rats were divided into five groups: basal control (n = 8), sham operation (n = 8), torsion-detorsion plus saline (n = 8), torsion-detorsion plus CAPE (n = 8). and only torsion (n = 8). Rats in the sham operation group underwent a surgical procedure similar to the other groups but the adnexa was not torsioned. Rats in the torsion group were killed after 360degrees clockwise adnexal torsion for 3 It and ovaries were harvested. CAPE was injected intraperitoneally 30 min before detorsion in the CAPE/cletorsion group and saline was administered in the saline/detorsion group. After 3 h of adnexal detorsion, the rats in both groups were killed and adnexa were surgically removed. Results: MDA levels and XO activities in torsion-detorsion plus saline group increased significantly when compared to basal control, torsion and sham operation groups (P < 0.001). In the CAPE group, MDA levels and XO activities were lower than those of torsion-detorsion plus saline group, and differences between the two groups were statistically significant (P < 0.001). GSH levels in torsion-detorsion plus saline group were decreased significantly when compared to basal control and sham operation groups (P < 0.001). GSH levels in the CAPE group were higher than those of torsion-detorsion plus saline group, and differences between the two groups were statistically significant (P < 0.004). Morphologically, polymorphonuclear leukocytic infiltration and vascular dilatation were obvious in the ischernia-reperfusion damaged ovary, a change partially reversed by CAPE. Conclusions: These results suggest that administration of CAPE has beneficial effects in the prevention of ischemia-reperfusion injury of the ovaries. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2004.05.007
dc.identifier.endpage188en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue2en_US
dc.identifier.pmid15541855en_US
dc.identifier.scopus2-s2.0-8444236300en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2004.05.007
dc.identifier.urihttps://hdl.handle.net/11616/95517
dc.identifier.volume117en_US
dc.identifier.wosWOS:000225603800011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadnexal torsion-detorsionen_US
dc.subjectraten_US
dc.subjectGSHen_US
dc.subjectMDAen_US
dc.subjectXOen_US
dc.titleThe protective effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in rat ovaryen_US
dc.typeArticleen_US

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