Retrospective Review of Patients with Staphylococcus aureus Bacteremia

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dc.authoridDuman, Yucel/0000-0002-9090-2096
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authorwosidDuman, Yucel/AAU-6221-2020
dc.authorwosidKose, Adem/AAD-1226-2020
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.contributor.authorYilmaz, Zeynep Burcin
dc.contributor.authorDuman, Yuecel
dc.contributor.authorAltunisik Toplu, Sibel
dc.contributor.authorMemisoglu, Funda
dc.contributor.authorKose, Adem
dc.contributor.authorOzden, Mehmet
dc.contributor.authorBayindir, Yasar
dc.date.accessioned2024-08-04T20:11:44Z
dc.date.available2024-08-04T20:11:44Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Staphylococcus aureus causes community-acquired and healthcare-associated infections with high morbidity and mortality. It is critical to initiate appropriate and effective treatment considering the risk factors for S. aureus bacteremia. There is insufficient data available regarding this patient group in our region. This study aimed to assess the focus of infection, resistance status, and clinical course in patients with S. aureus bacteremia detected in blood culture. Materials and Methods: Patients with healthcare-associated or community-acquired S. aureus bacteremia who were hospitalized in a tertiary hospital during the one year between January 2020 and December 2020, and microbiological data were retrospectively analyzed. The distribution of Staphylococcus aureus bacteremia was evaluated based on the organ involved, the clinics where it was observed, and its resistance status. Results: OStaphylococcus aureus isolate growth was detected in the blood cultures of 66 adult patients within one year. The mean age of the patients was 56.5 +/- 16.8 (18-84) years, and 76% were male. While bacteremia was community-acquired in 12 (18.2%) of the patients, it was healthcare-related in 54 (81.8%) and methicillin resistance rates were 8.3% and 25.9%, respectively. The most common focus of infection was catheter-related bloodstream infection in 21.2% and pneumonia in 21.2% of patients. No focus was detected in 34.8% of the bacteremias. In terms of methicillin-resistant S. aureus (MRSA) distribution, the difference between intensive care and wards was 20% and 80%, respectively. No statistically significant difference was found (p> 0.05). While the 14-day mortality in MRSA bacteremia was 33.6%, the 14-day mortality in methicillin-susceptible S. aureus was 27.5% (p= 0.731). Conclusion: It was found that Staphylococcus aureus bacteremia was predominantly nosocomial, with pneumonia and catheter infections being the most common causes. The conclusion drawn suggests a need for heightened infection control measures, particularly focusing on improving hand hygiene practices. To guide empirical treatment effectively, it is crucial to monitor resistance changes that may have occurred over the years, consider risk factors for MRSA, and elucidate the resistance profiles specific to individual healthcare facilities.en_US
dc.identifier.doi10.5578/flora.202402961
dc.identifier.endpage200en_US
dc.identifier.issn1300-932X
dc.identifier.issn2602-2842
dc.identifier.issue2en_US
dc.identifier.startpage194en_US
dc.identifier.trdizinid1242357en_US
dc.identifier.urihttps://doi.org/10.5578/flora.202402961
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1242357
dc.identifier.urihttps://hdl.handle.net/11616/92960
dc.identifier.volume29en_US
dc.identifier.wosWOS:001258536800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofFlora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectMRSAen_US
dc.subjectBacteremiaen_US
dc.subjectCommunity-acquireden_US
dc.subjectHealthcare-associateden_US
dc.titleRetrospective Review of Patients with Staphylococcus aureus Bacteremiaen_US
dc.typeArticleen_US

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