The effect of therapeutic plasma exchange on management of HELLP Syndrome: The report of 47 patients

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dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridKARAMAN, SEVTAP/0000-0001-5099-4582
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorSarici, Ahmet
dc.contributor.authorKuku, Irfan
dc.contributor.authorBerber, Ilhami
dc.contributor.authorKaya, Emin
dc.contributor.authorBicim, Soykan
dc.contributor.authorKaraman, Sevtap
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: HELLP syndrome is a life-threatening condition that may potentially cause complications during pregnancy. If not diagnosed and treated quickly, HELLP syndrome may lead to serious complications both for the mother and the baby. The aim of this study was to determin the effectiveness of therapeutic plasma exchange (TPE) for treatment of Class-I HELLP syndrome. Materials and Methods: Laboratory results from 47 patients with Class-I HELLP syndrome patients who underwent TPE between 2011 and 2020 were recorded before and after the procedure. A central venous catheter was inserted, and TPE was performed in patients who had not responded to delivery, steroid, and supportive therapy (blood products, anti-hypertensive therapy, intravenous fluid administration, and antibiotics) within 24 hours after the diagnosis of Class I HELLP syndrome according to the Mississippi Criteria. Results: The average age of patients was 33 +/- 4.7 years (range; 21-39 years). A mean of 5 (range; 4 to 6) TPE sessions were performed. There was a statistically significant decrease in total bilirubin, lactic dehydrogenase, aspartate aminotransferase, and alanine aminotransferase levels in all patients, whereas a significant increase in platelet count was observed (p < 0.05). Furthermore, clinical and laboratory improvement was achieved. Conclusion: In all patients with HELLP syndrome, a dramatically clinical and laboratory improvement occurred after TPE. Our study suggests that postpartum use of TPE within 24 hours is an efficient treatment option for Class-I HELLP syndrome.en_US
dc.identifier.doi10.1016/j.transci.2021.103248
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34420883en_US
dc.identifier.scopus2-s2.0-85113656038en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103248
dc.identifier.urihttps://hdl.handle.net/11616/100165
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600038en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHELLP Syndromeen_US
dc.subjectTherapeutic Plasma Exchangeen_US
dc.subjectManagementen_US
dc.titleThe effect of therapeutic plasma exchange on management of HELLP Syndrome: The report of 47 patientsen_US
dc.typeArticleen_US

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