The relationships between blood pressure, blood glucose, and bone mineral density in postmenopausal Turkish women

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dc.authoridCOSKUN, Ebru INCI/0000-0003-4402-3725
dc.authoridkalkan, ali kemal/0000-0003-3553-7468
dc.authoridAçıkgöz, Abdullah Serdar/0000-0001-9355-7753
dc.authoridaslan, serkan/0000-0001-9112-5754
dc.authoridDincgez, Burcu/0000-0002-2697-7501
dc.authoridenhoş, asım/0000-0002-7479-7783
dc.authorwosidCOSKUN, Ebru INCI/ABI-8238-2020
dc.authorwosidkalkan, ali kemal/HJB-3230-2022
dc.authorwosidAçıkgöz, Abdullah Serdar/AAD-2053-2021
dc.authorwosidaslan, serkan/AAA-1121-2022
dc.authorwosidYUMRU, Ayse Ender/HMV-6766-2023
dc.authorwosidDincgez, Burcu/AAH-5248-2020
dc.authorwosidenhoş, asım/AAK-2720-2021
dc.contributor.authorCakmak, Huseyin Altug
dc.contributor.authorCakmak, Burcu Dincgez
dc.contributor.authorYumru, Ayse Ender
dc.contributor.authorAslan, Serkan
dc.contributor.authorEnhos, Asim
dc.contributor.authorKalkan, Ali Kemal
dc.contributor.authorCoskun, Ebru Inci
dc.date.accessioned2024-08-04T20:41:18Z
dc.date.available2024-08-04T20:41:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Hypertension, diabetes mellitus, and osteoporosis are important comorbidities commonly seen in postmenopausal women. The aim of the present study was to investigate the relationships between blood pressure, blood glucose, and bone mineral density (BMD) in postmenopausal Turkish women. Methods: In this cross-sectional study, 270 consecutive patients who were admitted to an outpatient clinic with vasomotor symptoms and/or at least 1 year of amenorrhea were included. The patients were categorized into three groups according to their blood pressure and metabolic status as follows: normotensive, hypertensive nondiabetics, and hypertensive diabetics. The T-and z-scores of the proximal femur and lumbar vertebrae were measured with the dual-energy X-ray absorptiometry method to assess the BMD of the study groups. Results: Lumbar vertebral T-scores (P<0.001), lumbar vertebral z-scores (P<0.003), and proximal femoral T-scores (P<0.001) were demonstrated to be significantly lower in the hypertensive diabetic group compared to the hypertensive nondiabetic and normotensive groups. Systolic blood pressure was significantly inversely correlated with lumbar vertebral T-scores (r=-0.382; P=0.001), lumbar vertebral z-scores (r=-0.290; P=0.001), and proximal femoral T-scores (r=-0.340; P=0.001). Moreover, diastolic blood pressure was significantly inversely correlated with lumbar vertebral T-scores (r=-0.318; P=0.001), lumbar vertebral z-scores (r=-0.340; P=0.001), and proximal femoral T-scores (r=-0.304; P=0.001). Hypertension (odds ratio [OR]: 2.541, 95% confidence interval [CI]: 1.46-3.48, P=0.003), diabetes mellitus (OR: 2.136, 95% CI: 1.254-3.678, P=0.006), and age (OR: 1.069, 95% CI: 1.007-1.163, P=0.022) were found to be significant independent predictors of osteopenia in a multivariate analysis, after adjusting for other risk parameters. Conclusion: The present study is the first to evaluate the relationships between blood pressure, blood glucose, and BMD in postmenopausal Turkish women. Moreover, both hypertension and diabetes were demonstrated as significant independent predictors of osteopenia in postmenopausal Turkish women. Clinicians should be aware of the high risk of developing osteopenia in diabetic hypertensive postmenopausal women.en_US
dc.identifier.doi10.2147/TCRM.S95017
dc.identifier.endpage1648en_US
dc.identifier.issn1178-203X
dc.identifier.pmid26586948en_US
dc.identifier.scopus2-s2.0-84946553371en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1641en_US
dc.identifier.urihttps://doi.org/10.2147/TCRM.S95017
dc.identifier.urihttps://hdl.handle.net/11616/97045
dc.identifier.volume11en_US
dc.identifier.wosWOS:000363785800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofTherapeutics and Clinical Risk Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypertensionen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subjectpostmenopausalen_US
dc.subjectbone mineral densityen_US
dc.titleThe relationships between blood pressure, blood glucose, and bone mineral density in postmenopausal Turkish womenen_US
dc.typeArticleen_US

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